Taking inspiration from the Ctr-1 Mets7 Cu(i) binding motif, effective hybrid catalysts have been developed for asymmetric Henry condensations under green conditions. The introduction of an unnatural dipeptide mimic allowed to increase the catalytic performance. Metal transporters' binding domains could be exploited as a strategy for designing hybrid catalysts for homogeneous catalysis.

Ctr-1 Mets7 motif inspiring new peptide ligands for Cu(i)-catalyzed asymmetric Henry reactions under green conditions / S. Pellegrino, G. Facchetti, A. Contini, M.L. Gelmi, E. Erba, R. Gandolfi, I. Rimoldi. - In: RSC ADVANCES. - ISSN 2046-2069. - 6:75(2016 Jul 22), pp. 71529-71533. [10.1039/c6ra16255j]

Ctr-1 Mets7 motif inspiring new peptide ligands for Cu(i)-catalyzed asymmetric Henry reactions under green conditions

S. Pellegrino
;
G. Facchetti
Secondo
;
A. Contini;M.L. Gelmi;E. Erba;R. Gandolfi
Penultimo
;
I. Rimoldi
Ultimo
2016-07-22

Abstract

Taking inspiration from the Ctr-1 Mets7 Cu(i) binding motif, effective hybrid catalysts have been developed for asymmetric Henry condensations under green conditions. The introduction of an unnatural dipeptide mimic allowed to increase the catalytic performance. Metal transporters' binding domains could be exploited as a strategy for designing hybrid catalysts for homogeneous catalysis.
Biotin-streptavidin technology; copper transport proteins; Alpha-amino-acids; artificial metalloenzymes; metallopeptide catalysts; secondary structure; CU-II; design; complexes; chemistry
Settore CHIM/06 - Chimica Organica
Settore CHIM/03 - Chimica Generale e Inorganica
Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/430026
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