BACKGROUND AND PURPOSE: Hypercoagulability increases the risk of arterial thrombosis; however, this effect may differ between various manifestations of arterial disease. METHODS: In this study, we compared the effect of coagulation factors as measures of hypercoagulability on the risk of ischaemic stroke (IS) and myocardial infarction (MI) by performing a systematic review of the literature. The effect of a risk factor on IS (relative risk for IS, RRIS) was compared with the effect on MI (RRMI) by calculating their ratio (RRR = RRIS/RRMI). A relevant differential effect was considered when RRR was >1+ its own standard error (SE) or <1-SE. RESULTS: We identified 70 publications, describing results from 31 study populations, accounting for 351 markers of hypercoagulability. The majority (203/351, 58%) had an RRR greater than 1. A larger effect on IS risk than MI risk (RRE>1+1SE) was found in 49/343 (14%) markers. Of these, 18/49 (37%) had an RRR greater than 1+2SE. On the opposite side, a larger effect on MI risk (RRR<1-1SE) was found in only 17/343 (5%) markers. CONCLUSIONS: These results suggest that hypercoagulability has a more pronounced effect on the risk of IS than that of MI.
Hypercoagulability Is a Stronger Risk Factor for Ischaemic Stroke than for Myocardial Infarction : a Systematic Review / A. Maino, F.R. Rosendaal, A. Algra, F. Peyvandi, B. Siegerink. - In: PLOS ONE. - ISSN 1932-6203. - 10:8(2015 Aug 07), pp. e0133523.1-e0133523.12.
|Titolo:||Hypercoagulability Is a Stronger Risk Factor for Ischaemic Stroke than for Myocardial Infarction : a Systematic Review|
MAINO, ALBERTO (Primo)
PAYVANDI, FLORA (Penultimo)
|Parole Chiave:||Biomarkers; Brain Ischemia; Humans; Myocardial Infarction; Risk Factors; Stroke; Thrombophilia; Thrombosis|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||7-ago-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1371/journal.pone.0133523|
|Appare nelle tipologie:||01 - Articolo su periodico|
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