After evaluating the prevalence of early endothelial dysfunction, as measured by means of reactive hyperemia in adolescents with type 1 diabetes, we started a 6-month, double-blind, randomized trial to test the efficacy of an antioxidant diet (± alpha-lipoic acid supplementation) to improve endothelial dysfunction. Seventy-one children and adolescents, ages 17 ± 3.9 yrs, with type 1 diabetes since 9.5 ± 5.3 yrs, using intensified insulin therapy, were randomized into 3 arms: (a) antioxidant diet 10.000 ORAC + alpha-lipoic acid; (b) antioxidant diet 10.000 ORAC + placebo; (c) controls. BMI, blood pressure, fasting lipid profile, HbA1c, insulin requirement, dietary habits, and body composition were determined in each patient. An antioxidant diet significantly improved endothelial dysfunction when supplemented with alpha-lipoic acid, unlike diet with placebo or controls. A significant reduction in bolus insulin was also observed. We speculate that alpha-lipoic acid might have an antioxidant effect in pediatric diabetes patients by reducing insulin.
Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes : a Pilot Trial / A. Scaramuzza, E. Giani, F. Redaelli, S. Ungheri, M. Macedoni, V. Giudici, A. Bosetti, M. Ferrari, G.V. Zuccotti. - In: JOURNAL OF DIABETES RESEARCH. - ISSN 2314-6745. - 2015(2015), pp. 47456.1-47456.7.
|Titolo:||Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes : a Pilot Trial|
GIANI, ELISA (Secondo)
ZUCCOTTI, GIAN VINCENZO (Ultimo)
|Parole Chiave:||Adolescent; Antioxidants; Cohort Studies; Combined Modality Therapy; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Double-Blind Method; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Hyperemia; Hypoglycemic Agents; Insulin; Male; Oxidative Stress; Pilot Projects; Risk; Thioctic Acid; Adolescent Nutritional Physiological Phenomena; Dietary Supplements; Functional Food|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1155/2015/474561|
|Appare nelle tipologie:||01 - Articolo su periodico|