Drug-loaded contact lenses are emerging as the preferred treatment method for several ocular diseases, and efforts are being directed to promote extended and controlled delivery. One strategy is based on delivery induced by environmental triggers. One of these triggers can be hydrogen peroxide, since many platforms based on drug-loaded nanoparticles were demonstrated to be hydrogen-peroxide responsive. This is particularly interesting when hydrogen peroxide is the result of a specific pathophysiological condition. Otherwise, an alternative route to induce drug delivery is here proposed, namely the mechano-synthesis. The present work represents the proof-of-concept of the mechanosynthesis of hydrogen peroxide in siloxane-hydrogel contact lenses as a consequence of the cleavage of siloxane bonds at the interface between the polymer and water in aqueous phase. Their spongy morphology makes contact lenses promising systems for mechanical-to-chemical energy conversion, since the amount of hydrogen peroxide is expected to scale with the interfacial area between the polymer and water. The eyelid pressure during wear is sufficient to induce the hydrogen peroxide synthesis with concentrations which are biocompatible and suitable to trigger the drug release through hydrogen-peroxide-responsive platforms. For possible delivery on demand, the integration of piezoelectric polymers in the siloxanehydrogel contact lenses could be designed, whose mechanical deformation could be induced by an applied wireless-controlled voltage.
Hydrogen peroxide mechanosynthesis in siloxane-hydrogel contact lenses / S. Tavazzi, L. Ferraro, F. Cozza, V. Pastori, M. Lecchi, S. Farris, A. Borghesi. - In: ACS APPLIED MATERIALS & INTERFACES. - ISSN 1944-8244. - 6:22(2014 Nov 26), pp. 19606-19612. [10.1021/am503940p]
Hydrogen peroxide mechanosynthesis in siloxane-hydrogel contact lenses
S. FarrisPenultimo
;
2014
Abstract
Drug-loaded contact lenses are emerging as the preferred treatment method for several ocular diseases, and efforts are being directed to promote extended and controlled delivery. One strategy is based on delivery induced by environmental triggers. One of these triggers can be hydrogen peroxide, since many platforms based on drug-loaded nanoparticles were demonstrated to be hydrogen-peroxide responsive. This is particularly interesting when hydrogen peroxide is the result of a specific pathophysiological condition. Otherwise, an alternative route to induce drug delivery is here proposed, namely the mechano-synthesis. The present work represents the proof-of-concept of the mechanosynthesis of hydrogen peroxide in siloxane-hydrogel contact lenses as a consequence of the cleavage of siloxane bonds at the interface between the polymer and water in aqueous phase. Their spongy morphology makes contact lenses promising systems for mechanical-to-chemical energy conversion, since the amount of hydrogen peroxide is expected to scale with the interfacial area between the polymer and water. The eyelid pressure during wear is sufficient to induce the hydrogen peroxide synthesis with concentrations which are biocompatible and suitable to trigger the drug release through hydrogen-peroxide-responsive platforms. For possible delivery on demand, the integration of piezoelectric polymers in the siloxanehydrogel contact lenses could be designed, whose mechanical deformation could be induced by an applied wireless-controlled voltage.File | Dimensione | Formato | |
---|---|---|---|
Pre-print.pdf
accesso riservato
Tipologia:
Pre-print (manoscritto inviato all'editore)
Dimensione
998.47 kB
Formato
Adobe PDF
|
998.47 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
am503940p.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
2.07 MB
Formato
Adobe PDF
|
2.07 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.