Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only significantly present in grape products, a huge amount of preclinical studies investigated its anticancer properties in a plethora of cellular and animal models. Molecular mechanisms of resveratrol involved signaling pathways related to extracellular growth factors and receptor tyrosine kinases; formation of multiprotein complexes and cell metabolism; cell proliferation and genome instability; cytoplasmic tyrosine kinase signaling (cytokine, integrin, and developmental pathways); signal transduction by the transforming growth factor-β super-family; apoptosis and inflammation; and immune surveillance and hormone signaling. Resveratrol also showed a promising role to counteract multidrug resistance: in adjuvant therapy, associated with 5-fluoruracyl and cisplatin, resveratrol had additive and/or synergistic effects increasing the chemosensitization of cancer cells. Resveratrol, by acting on diverse mechanisms simultaneously, has been emphasized as a promising, multi-target, anticancer agent, relevant in both cancer prevention and treatment.
Anticancer Molecular Mechanisms of Resveratrol / E. Varoni, A. Lo Faro, J. Sharifi-Rad, M. Iriti. - In: FRONTIERS IN NUTRITION. - ISSN 2296-861X. - 3(2016 Apr 12), pp. 8.1-8.15.
|Titolo:||Anticancer Molecular Mechanisms of Resveratrol|
VARONI, ELENA MARIA (Primo)
LO FARO, ALFREDO FABRIZIO FRANCESCO (Secondo)
IRITI, MARCELLO (Ultimo)
|Parole Chiave:||bioavailability; cancer chemoprevention; multi-target agents; nutritional therapy; polyphenols; stilbenes|
|Settore Scientifico Disciplinare:||Settore CHIM/10 - Chimica degli Alimenti|
|Data di pubblicazione:||12-apr-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3389/fnut.2016.00008|
|Appare nelle tipologie:||01 - Articolo su periodico|