The invention relates to prepn. of oxohydroxyphenyl retinamide derivs of formula I wherein: X is -COOH or NH2; R is a straight or branched C1-C10 alkylene chain; and R1 is H, straight or branched C1-C10 alkyl, aryl, or R2CO- wherein R2 is straight or branched C1-C10 alkyl, or a pharmaceutically acceptable salt thereof for the treatment of cancer. Compds. I belong to retinoid family that are are natural and synthetic derivs. of vitamin A (retinol) which modulate various cell processes, such as proliferation, differentiation and apoptosis.
4-oxo-n-(4-hydroxyphenyl)retinamide derivatives as therapeutic agents for the treatment of cancer / Daidone, G. Maria, V. Appierto, P. Tiberio, S. Dallavalle, L. Musso, E. Niccolini.
4-oxo-n-(4-hydroxyphenyl)retinamide derivatives as therapeutic agents for the treatment of cancer
S. Dallavalle;L. Musso;
2016
Abstract
The invention relates to prepn. of oxohydroxyphenyl retinamide derivs of formula I wherein: X is -COOH or NH2; R is a straight or branched C1-C10 alkylene chain; and R1 is H, straight or branched C1-C10 alkyl, aryl, or R2CO- wherein R2 is straight or branched C1-C10 alkyl, or a pharmaceutically acceptable salt thereof for the treatment of cancer. Compds. I belong to retinoid family that are are natural and synthetic derivs. of vitamin A (retinol) which modulate various cell processes, such as proliferation, differentiation and apoptosis.
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