We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recorded using a vertical spectrometer, and the volume of cerebrospinal fluid (CSF) in this part of the vertebral canal was calculated. The findings of the present study demonstrate that: (i) there was a significant decrease in cervical tract CSF volume regardless of the way in which the vitamin deficiency was induced; (ii) this volume normalized in the totally gastrectomized rats after chronic Cbl treatment; (iii) no blood-brain or blood-CSF barrier lesions were found in Cbl-D rats, using either MRI with a paramagnetic contrast agent or calculating the albumin CSF/serum concentration quotient. Cbl deficiency decreases CSF volume in the cervical tract of the vertebral canal of the rat, without apparently impairing the blood-brain barrier.
|Titolo:||Cobalamin deficiency-induced changes in magnetic resonance imaging of cerebrospinal fluid volume in the cervical tract in the rat|
|Autori interni:||SCALABRINO, GIUSEPPE (Ultimo)|
VEBER, DANIELA (Primo)
MUTTI, ELENA (Secondo)
GIANAZZA, ELISABETTA (Penultimo)
|Parole Chiave:||Cerebrospinal fluid; Cobalamin; Cobalamin deficiency; Magnetic resonance imaging; Total gastrectomy|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
|Data di pubblicazione:||8-ago-2008|
|Digital Object Identifier (DOI):||10.1016/j.neulet.2008.05.079|
|Appare nelle tipologie:||01 - Articolo su periodico|
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