The catalytic asymmetric hydrogenation of prochiral ketones was carried out with Ru(II) complexes prepared from new chiral diphosphine ligands, cis (R,R)-2,5-bis[(diarylphosphino)]-3-hexenes. These new ligands were prepared from optically pure (R,R) or (S,S)-Z-3-hexene-2,5 diol and enantiomeric excesses up to 85 % were obtained in the reduction of 2-benzamidomethyl-3-oxobutanoate, starting material for the synthesis of 4-acetoxy-2-azetidinone.
Chiral 1,4-bis-diphosphine ligands from optically active (Z)-olefines / E. Cesarotti, I. Rimoldi, P. Spalluto, F. Demartin. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 18:11(2007), pp. 1278-1283. [10.1016/j.tetasy.2007.04.018]
Chiral 1,4-bis-diphosphine ligands from optically active (Z)-olefines
E. CesarottiPrimo
;I. RimoldiSecondo
;P. SpallutoPenultimo
;F. DemartinUltimo
2007
Abstract
The catalytic asymmetric hydrogenation of prochiral ketones was carried out with Ru(II) complexes prepared from new chiral diphosphine ligands, cis (R,R)-2,5-bis[(diarylphosphino)]-3-hexenes. These new ligands were prepared from optically pure (R,R) or (S,S)-Z-3-hexene-2,5 diol and enantiomeric excesses up to 85 % were obtained in the reduction of 2-benzamidomethyl-3-oxobutanoate, starting material for the synthesis of 4-acetoxy-2-azetidinone.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
