A highly crosslinked composite dextran-based scaffold (named DexFoam) was tailored to overcome specific deficiencies of polymeric and ceramic bone scaffolds and to guarantee a bone-mimicking microenvironment for the proliferation of human mesenchymal stem cells in vitro . The creep resistance for up to 90% compressive stain, the capability to regain the original shape after deformation, and the good thermal stability in both physiological and “body limit” conditions make DexFoam a valid alternative to the currently available bone scaffolds. Histopathological evaluation for host reaction and tissue colonization of DexFoam scaffold, implanted subcutaneously in mice, demonstrated its in vivo biocompatibility and biodegradability
Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering : synthesis, chemico-physical characterization, andin vitroandin vivobiocompatibility / I. Gerges, M. Tamplenizza, S. Lopa, C. Recordati, F. Martello, A. Tocchio, L. Ricotti, C. Arrigoni, P. Milani, M. Moretti, C. Lenardi. - In: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS. - ISSN 0091-4037. - 65:14(2016), pp. 729-740. [10.1080/00914037.2016.1163565]
Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering : synthesis, chemico-physical characterization, andin vitroandin vivobiocompatibility
I. GergesPrimo
;M. TamplenizzaSecondo
;S. Lopa;C. Recordati;F. Martello;A. Tocchio;C. Arrigoni;P. Milani;C. LenardiUltimo
2016
Abstract
A highly crosslinked composite dextran-based scaffold (named DexFoam) was tailored to overcome specific deficiencies of polymeric and ceramic bone scaffolds and to guarantee a bone-mimicking microenvironment for the proliferation of human mesenchymal stem cells in vitro . The creep resistance for up to 90% compressive stain, the capability to regain the original shape after deformation, and the good thermal stability in both physiological and “body limit” conditions make DexFoam a valid alternative to the currently available bone scaffolds. Histopathological evaluation for host reaction and tissue colonization of DexFoam scaffold, implanted subcutaneously in mice, demonstrated its in vivo biocompatibility and biodegradabilityPubblicazioni consigliate
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