We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position-592,-819,-1082), IL-6 (-174), transforming growth factor-β1 (TGF-β1) (-10,-25), interferon-γ (IFN-γ) (-874), and tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. IL-10 production after Aβ stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-γ low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.
Interleukin-10 Production in Response to Amyloid-β Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease / D. Asselineau, K. Benlhassan, B. Arosio, D. Mari, E. Ferri, M. Casati, C. Gussago, E. Tedone, G. Annoni, P. Mazzola, F. Piette, J. Belmin, S. Pariel, A. Bornand, J. Beaudeux, M. Doulazmi, J. Mariani, D.H. Bray. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 46:4(2015), pp. 837-842. [10.3233/JAD-142832]
Interleukin-10 Production in Response to Amyloid-β Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease
B. Arosio;D. Mari;E. Ferri;M. Casati;C. Gussago;E. Tedone;
2015
Abstract
We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position-592,-819,-1082), IL-6 (-174), transforming growth factor-β1 (TGF-β1) (-10,-25), interferon-γ (IFN-γ) (-874), and tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. IL-10 production after Aβ stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-γ low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.
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