Background: Scanty data exist on the role of personal medical conditions, except for gallstones, and family history of cancer on the risk of biliary tract cancers (BTC). Methods: We analyzed this issue using data from two Italian case-control studies, including 159 cases of BTC and 795 matched hospital controls. Odds ratios (ORs) of BTC and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression models. Results: Gallstones were associated with a 2-fold excess risk of BTC (95% CI 1.24-3.45). No significant associations were observed with other conditions investigated, including diabetes (OR 1.15, 95% CI 0.63-2.11), hypertension (OR 0.65, 95% CI 0.39-1.11), hyperlipidemia (OR 0.61, 95% CI 0.31-1.21), allergy (OR 0.64, 95% CI 0.29-1.40), gastroduodenal ulcer (OR 0.52, 95% CI 0.24-1.12), hepatitis (OR 2.02, 95% CI 0.35-11.67), benign thyroid diseases (OR 1.16, 95% CI 0.56-2.40), hysterectomy (OR 1.19, 95% CI 0.53-2.68), unilateral oophorectomy (OR 1.75, 95% CI 0.44-6.93), and bilateral oophorectomy (OR 2.48, 95% CI 0.79-7.82). We found an excess risk of BTC in relation to family history of any cancer (OR 1.52, 95% CI 1.03-2.24) and family history of gallbladder cancer (OR 3.83, 95% CI 0.59-24.75). Conclusions: The present study confirms a strong association between BTC and history of gallstones, and provides further evidence of a positive association with family history of cancer.
Medical conditions, family history of cancer, and the risk of biliary tract cancers / V. Rosato, C. Bosetti, L. Dal Maso, M. Montella, D. Serraino, E. Negri, C. La Vecchia. - In: TUMORI. - ISSN 0300-8916. - 102:3(2016), pp. 252-257.
|Titolo:||Medical conditions, family history of cancer, and the risk of biliary tract cancers|
|Parole Chiave:||Biliary tract cancers; Family history of cancer; Gallbladder cancer; Gallstones|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||2016|
|Data ahead of print / Data di stampa:||4-ago-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.5301/tj.5000397|
|Appare nelle tipologie:||01 - Articolo su periodico|