Background: Scanty data exist on the role of personal medical conditions, except for gallstones, and family history of cancer on the risk of biliary tract cancers (BTC). Methods: We analyzed this issue using data from two Italian case-control studies, including 159 cases of BTC and 795 matched hospital controls. Odds ratios (ORs) of BTC and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression models. Results: Gallstones were associated with a 2-fold excess risk of BTC (95% CI 1.24-3.45). No significant associations were observed with other conditions investigated, including diabetes (OR 1.15, 95% CI 0.63-2.11), hypertension (OR 0.65, 95% CI 0.39-1.11), hyperlipidemia (OR 0.61, 95% CI 0.31-1.21), allergy (OR 0.64, 95% CI 0.29-1.40), gastroduodenal ulcer (OR 0.52, 95% CI 0.24-1.12), hepatitis (OR 2.02, 95% CI 0.35-11.67), benign thyroid diseases (OR 1.16, 95% CI 0.56-2.40), hysterectomy (OR 1.19, 95% CI 0.53-2.68), unilateral oophorectomy (OR 1.75, 95% CI 0.44-6.93), and bilateral oophorectomy (OR 2.48, 95% CI 0.79-7.82). We found an excess risk of BTC in relation to family history of any cancer (OR 1.52, 95% CI 1.03-2.24) and family history of gallbladder cancer (OR 3.83, 95% CI 0.59-24.75). Conclusions: The present study confirms a strong association between BTC and history of gallstones, and provides further evidence of a positive association with family history of cancer.
Medical conditions, family history of cancer, and the risk of biliary tract cancers / V. Rosato, C. Bosetti, L. Dal Maso, M. Montella, D. Serraino, E. Negri, C. La Vecchia. - In: TUMORI. - ISSN 0300-8916. - 102:3(2016), pp. 252-257.
Titolo: | Medical conditions, family history of cancer, and the risk of biliary tract cancers |
Autori: | |
Parole Chiave: | Biliary tract cancers; Family history of cancer; Gallbladder cancer; Gallstones |
Settore Scientifico Disciplinare: | Settore MED/01 - Statistica Medica |
Data di pubblicazione: | 2016 |
Rivista: | |
Tipologia: | Article (author) |
Data ahead of print / Data di stampa: | 4-ago-2015 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.5301/tj.5000397 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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