The aim of this study was to estimate prognostic factors in a Dalmatian dog with bilateral cryptorchidism and hypospadias. Cytogenetic and molecular analyses revealed a normal karyotype (2n = 78,XY) and the presence of SRY, INSL3 and RXFP2 genes with a normal DNA sequence for SRY and RXFP2, while the INSL3 sequence differed slightly from the normal one due to a heterozygous nucleotide change involving amino acid 22 of the INSL3 dog precursor protein. Levels of plasmatic testosterone were only 0.01 ng/ml, while FSH and LH serum levels were not detectable. After the human chorionic gonadotropin (hCG) test, the serum testosterone level was 0.01 ng/ml. Therefore, the phenotypic aetiology of this subject can not be well-defined because cryptorchidism and hypospadias were frequent clinical features with high genetic heterogeneity. Copyright
Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadias / R. Cassata, A. Iannuzzi, P. Parma, L. De Lorenzi, V. Peretti, A. Perucatti, L. Iannuzzi, G.P Di Meo. - In: CYTOGENETIC AND GENOME RESEARCH. - ISSN 1424-8581. - 120:1-2(2008), pp. 140-143.
|Titolo:||Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadias|
|Settore Scientifico Disciplinare:||Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico|
|Data di pubblicazione:||2008|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000118753|
|Appare nelle tipologie:||01 - Articolo su periodico|