Background: Recurrent pneumonia (RP) is one of the most frequent causes of pediatric non-cystic fibrosis (CF) bronchiectasis (BE) and a consequent accelerated decline in lung function. The aim of this study was to analyse the clinical records of children with RP in attempt to identify factors that may lead to an early suspicion of non-CF BE. Methods: We recorded the demographic and clinical data, and lung function test results of children without CF attending our outpatient RP clinic between January 2009 to December 2013 who had undergone chest high-resolution computed tomography ≥8 weeks after an acute pneumonia episode and ≤6 months before enrolment. Results: The study involved 42 patients with RP: 21 with and 21 without non-CF BE. The most frequent underlying diseases in both groups were chronic rhinosinusitis with post-nasal drip and recurrent wheezing (81 % and 71.4 % of those with, and 85.7 % and 71.4 % of those without BE). FEV1 and FEF25-75 values were significantly lower in the children with non-CF BE than in those without (77.9 ± 17.8 vs 96.8 ± 12.4, p = 0.004; 69.3 ± 25.6 vs 89.3 ± 21.9, p = 0.048). Bronchodilator responsiveness was observed in seven children with BE (33.3 %) and two without (9.5 %; p = 0.13). Conclusions: Reduced FEV1 and FEF25-75 values seem associated with an increased risk of developing non-CF BE in children with RP. This suggests a need for further studies to confirm the diagnostic usefulness use of spirometry in such cases.
Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis / M.F. Patria, B. Longhi, M. Lelii, C. Tagliabue, M. Lavelli, C. Galeone, N. Principi, S. Esposito. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - 42:1(2016 Feb 09), pp. 13.1-13.7.
|Titolo:||Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis|
PRINCIPI, NICOLA (Penultimo)
ESPOSITO, SUSANNA (Corresponding)
|Parole Chiave:||Bronchiectasis; Lower respiratory tract infections; Non-cystic fibrosis bronchiectasis; Pediatric pulmonology; Pneumonia; Recurrent pneumonia|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
Settore MED/01 - Statistica Medica
|Data di pubblicazione:||9-feb-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1186/s13052-016-0225-z|
|Appare nelle tipologie:||01 - Articolo su periodico|