Articular cartilage lesions have a poor intrinsic healing potential. The repair tissue is often fibrous, having insufficient biomechanical properties, which could frequently lead to the development of early osteoarthritis. In the last decade, tissue engineering approaches addressed this topic in order to restore joint function with a differentiated and functional tissue. Many biomaterials and techniques have been proposed and some of them applied in clinical practice, even though several concerns have been raised on the quality of the engineered tissue and on its integration in the host joint. In this study, we focused on engineering in vitro a biphasic composite made of cellular fibrin glue and a calcium–phosphate scaffold. Biphasic composites are the latest products of tissue engineering applied to articular cartilage and they seem to allow a more efficient integration of the engineered tissue with the host. However, a firm in vitro bonding between the two components of the composite is a necessary condition to validate this model. Our study demonstrated a gross and microscopic integration of the two components and a cartilage-like quality of the newly formed matrix. Moreover, we noticed an improvement of this integration and GAGs production during the in vitro culture.
A tissue engineered osteochondral plug : an in vitro morphological evaluation / C. Scotti, M.S. Buragas, L. Mangiavini, C. Sosio, A. Di Giancamillo, C. Domeneghini, G. Fraschini, G.M. Peretti. - In: KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY. - ISSN 0942-2056. - 15:11(2007 Nov), pp. 1363-1369.
|Titolo:||A tissue engineered osteochondral plug : an in vitro morphological evaluation|
|Parole Chiave:||articular cartilage; osteochondral repair; tissue engineering; scaffold; fibrin glue|
|Settore Scientifico Disciplinare:||Settore VET/01 - Anatomia degli Animali Domestici|
Settore MED/33 - Malattie Apparato Locomotore
|Data di pubblicazione:||nov-2007|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00167-007-0359-z|
|Appare nelle tipologie:||01 - Articolo su periodico|