Clinical and experimental evidence have highlighted that a major leukocyte population present in tumours, the so-called tumour-associated macrophages (TAM), is the principal component of the leukocyte infiltrate supporting tumour growth. Over the years the mechanisms supporting the protumoural functions of TAM have become increasingly clear and in several experimental tumour models, the activation of an inflammatory response (most frequently mediated by macrophages) has been shown to play an essential role for full neoplastic transformation and progression. This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies.

Targeting tumour-associated macrophages / A. Sica, L. Rubino, A. Mancino, P. Larghi, C. Porta, M. Rimoldi, G. Solinas, M. Locati, P. Allavena, A. Mantovani. - In: EXPERT OPINION ON THERAPEUTIC TARGETS. - ISSN 1472-8222. - 11:9(2007 Sep), pp. 1219-1229.

Targeting tumour-associated macrophages

L. Rubino;A. Mancino;P. Larghi;G. Solinas;M. Locati;A. Mantovani
2007-09

Abstract

Clinical and experimental evidence have highlighted that a major leukocyte population present in tumours, the so-called tumour-associated macrophages (TAM), is the principal component of the leukocyte infiltrate supporting tumour growth. Over the years the mechanisms supporting the protumoural functions of TAM have become increasingly clear and in several experimental tumour models, the activation of an inflammatory response (most frequently mediated by macrophages) has been shown to play an essential role for full neoplastic transformation and progression. This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies.
Macrophage polarisation; Tumour promotion; Tumour-associated macrophage
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/36410
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