We tested real-time sonoelastography (RTS) in-vivo to differentiate fibrotic from inflammatory terminal ileum strictures in patients with Crohn's disease (CD), using magnetic resonance enterography (MRE) as a reference standard. Sixteen patients (13 male, 3 female; median [interquartile interval] age = 41 [31-48.5] y; median C-reactive protein (CRP) = 0.95 [0-2.23] mg/dL; median disease duration = 108.5 [35-213.75] mo; median Harvey-Bradshaw Index (HBI) = 3 [3-5.25]) with terminal ileum CD were prospectively included. Short-axis scans were performed; each cross-section was ideally sub-divided into eight circular sectors. Color map provided by RTS was translated into semi-quantitative scale (1 = red; 2 = green; 3 = blue). At MRE, inflammation was seen in nine patients and fibrosis in seven. Total median RTS score was significantly lower in patients with inflammatory stricture (16 [16-18]) than in patients with fibrosis (20 [17.5-22]; p = 0.003). The same happened when the four most superficial quadrants of the loop were considered (8 [7-9] vs. 10 [9-11.5]; p = 0.003). No significant correlation was seen between RTS and HBI (r = 0.467; p = 0.686), RTS and CRP (r = -0.750; p = 0.567) or RTS and disease duration (r = 0.238; p = 0.483). RTS of the terminal ileum in patients with CD is feasible in-vivo, potentially differentiating between fibrotic and inflammatory strictures.
In-vivo axial-strain sonoelastography helps distinguish acutely-inflamed from fibrotic terminal ileum strictures in patients with Crohn's disease : preliminary results / L.M. Sconfienza, F. Cavallaro, V. Colombi, L. Pastorelli, G. Tontini, L. Pescatori, A. Esseridou, E. Savarino, C. Messina, R. Casale, G. Di Leo, F. Sardanelli, M. Vecchi. - In: ULTRASOUND IN MEDICINE AND BIOLOGY. - ISSN 0301-5629. - 42:4(2016 Apr), pp. 855-863.
|Titolo:||In-vivo axial-strain sonoelastography helps distinguish acutely-inflamed from fibrotic terminal ileum strictures in patients with Crohn's disease : preliminary results|
SCONFIENZA, LUCA MARIA (Primo)
CAVALLARO, FLAMINIA (Secondo)
SARDANELLI, FRANCESCO (Penultimo)
VECCHI, MAURIZIO (Ultimo)
|Parole Chiave:||axial-strain sonoelastography; Crohn's disease; fibrosis; inflammation; stricture|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Data di pubblicazione:||apr-2016|
|Data ahead of print / Data di stampa:||29-dic-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ultrasmedbio.2015.11.023|
|Appare nelle tipologie:||01 - Articolo su periodico|