We describe the synthesis of new hydrazinoPNA (hydPNA) monomers and new hydPNA-containing dimers. For the hydPNA monomers, the primary terminal amino group of the aminoethylglycine unit of classical aegPNA is replaced by a hydrazine moiety. An appropriate choice of two orthogonal protecting groups on the two hydrazine nitrogen atoms makes it possible to drive their coupling with other monomers selectively on one or the other nitrogen atom, thus obtaining two different types of PNA dimers. These dimers represent new building blocks that can be used to generate novel PNA oligomers.

Synthesis of hydrazino-peptide nucleic acid monomers and dimers as new PNA backbone building blocks / P. Cerea, C. Giannini, S. Dall'Angelo, E. Licandro, S. Maiorana, R. Marchelli. - In: TETRAHEDRON. - ISSN 0040-4020. - 63:19(2007), pp. 4108-4119.

Synthesis of hydrazino-peptide nucleic acid monomers and dimers as new PNA backbone building blocks

P. Cerea
Primo
;
C. Giannini
Secondo
;
S. Dall'Angelo;E. Licandro;S. Maiorana
Penultimo
;
2007

Abstract

We describe the synthesis of new hydrazinoPNA (hydPNA) monomers and new hydPNA-containing dimers. For the hydPNA monomers, the primary terminal amino group of the aminoethylglycine unit of classical aegPNA is replaced by a hydrazine moiety. An appropriate choice of two orthogonal protecting groups on the two hydrazine nitrogen atoms makes it possible to drive their coupling with other monomers selectively on one or the other nitrogen atom, thus obtaining two different types of PNA dimers. These dimers represent new building blocks that can be used to generate novel PNA oligomers.
Settore CHIM/06 - Chimica Organica
2007
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/35657
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