The regioselective synthesis of 5-substituted-3-dimethoxyphosphono-pyrazoles and -2-pyrazolines has been accomplished through the 1,3-dipolar cycloaddition of a suitable nitrile imine to monosubstituted alkynes and alkenes. Examples of hydrolysis of the heterocyclic phosphonic esters to the corresponding acids are described.
A regioselective route to 5-substituted pyrazole- and pyrazoline-3-phosphonic acids and esters / P. Conti, A. Pinto, L. Tamborini, V. Rizzo, C. De Micheli. - In: TETRAHEDRON. - ISSN 0040-4020. - 63:25(2007 Jun 18), pp. 5554-5560. [10.1016/j.tet.2007.04.027]
A regioselective route to 5-substituted pyrazole- and pyrazoline-3-phosphonic acids and esters
P. Conti
Primo
;A. PintoSecondo
;L. Tamborini;V. RizzoPenultimo
;C. De MicheliUltimo
2007
Abstract
The regioselective synthesis of 5-substituted-3-dimethoxyphosphono-pyrazoles and -2-pyrazolines has been accomplished through the 1,3-dipolar cycloaddition of a suitable nitrile imine to monosubstituted alkynes and alkenes. Examples of hydrolysis of the heterocyclic phosphonic esters to the corresponding acids are described.File in questo prodotto:
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