One of the most critical quality attributes of orodispersible films (ODFs) is related to the development of dosage forms with tensile properties suitable for the packaging and patient's handling. Aiming to develop a strategy to reinforce the tensile properties, the current work reported the feasibility to improve the tensile strength of maltodextrins (MDX) based ODFs by adding an amorphous water insoluble nanofiller, namely polyvinylacetate (PVAc). The possible interactions between components investigated by DSC and ATR-FTIR spectroscopy revealed that MDX and PVAc were immiscible; even if, the presence of plasticizers permitted the homogeneous dispersion of PVAc in the film until the 10% w/w concentration was reached. As a consequence, PVAc nanoparticles was found to be an effective reinforcing agent only at the concentrations of 3 and 5% w/w. In this optimal range, the tensile strength increased at least 1.5 fold and the elastic modulus increased at least 4 times.

Nanofiller for the mechanical reinforcement of maltodextrins orodispersible films / I. Franceschini, F. Selmin, S. Pagani, P. Minghetti, F. Cilurzo. - In: CARBOHYDRATE POLYMERS. - ISSN 0144-8617. - 136:(2016 Jan 20), pp. 10379.676-10379.681. [10.1016/j.carbpol.2015.09.077]

Nanofiller for the mechanical reinforcement of maltodextrins orodispersible films

I. Franceschini
Primo
;
F. Selmin
Secondo
;
S. Pagani;P. Minghetti
Penultimo
;
F. Cilurzo
2016

Abstract

One of the most critical quality attributes of orodispersible films (ODFs) is related to the development of dosage forms with tensile properties suitable for the packaging and patient's handling. Aiming to develop a strategy to reinforce the tensile properties, the current work reported the feasibility to improve the tensile strength of maltodextrins (MDX) based ODFs by adding an amorphous water insoluble nanofiller, namely polyvinylacetate (PVAc). The possible interactions between components investigated by DSC and ATR-FTIR spectroscopy revealed that MDX and PVAc were immiscible; even if, the presence of plasticizers permitted the homogeneous dispersion of PVAc in the film until the 10% w/w concentration was reached. As a consequence, PVAc nanoparticles was found to be an effective reinforcing agent only at the concentrations of 3 and 5% w/w. In this optimal range, the tensile strength increased at least 1.5 fold and the elastic modulus increased at least 4 times.
Casting solution; Maltodextrins; Mechanical reinforcement; Nanofiller; Orodispersible films; Tensile properties; Organic Chemistry; Materials Chemistry2506 Metals and Alloys; Polymers and Plastics
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
20-gen-2016
Article (author)
File in questo prodotto:
File Dimensione Formato  
CARBPOL-D-15-02024 annoted 030815.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 1.17 MB
Formato Adobe PDF
1.17 MB Adobe PDF Visualizza/Apri
FranceschiniCilurzo_CarbonhydratePolymers_Nanofiller_2016.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 826.03 kB
Formato Adobe PDF
826.03 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/345829
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 27
social impact