One of the most critical quality attributes of orodispersible films (ODFs) is related to the development of dosage forms with tensile properties suitable for the packaging and patient's handling. Aiming to develop a strategy to reinforce the tensile properties, the current work reported the feasibility to improve the tensile strength of maltodextrins (MDX) based ODFs by adding an amorphous water insoluble nanofiller, namely polyvinylacetate (PVAc). The possible interactions between components investigated by DSC and ATR-FTIR spectroscopy revealed that MDX and PVAc were immiscible; even if, the presence of plasticizers permitted the homogeneous dispersion of PVAc in the film until the 10% w/w concentration was reached. As a consequence, PVAc nanoparticles was found to be an effective reinforcing agent only at the concentrations of 3 and 5% w/w. In this optimal range, the tensile strength increased at least 1.5 fold and the elastic modulus increased at least 4 times.
Nanofiller for the mechanical reinforcement of maltodextrins orodispersible films / I. Franceschini, F. Selmin, S. Pagani, P. Minghetti, F. Cilurzo. - In: CARBOHYDRATE POLYMERS. - ISSN 0144-8617. - 136:(2016 Jan 20), pp. 10379.676-10379.681. [10.1016/j.carbpol.2015.09.077]
Nanofiller for the mechanical reinforcement of maltodextrins orodispersible films
I. FranceschiniPrimo
;F. SelminSecondo
;S. Pagani;P. MinghettiPenultimo
;F. Cilurzo
2016
Abstract
One of the most critical quality attributes of orodispersible films (ODFs) is related to the development of dosage forms with tensile properties suitable for the packaging and patient's handling. Aiming to develop a strategy to reinforce the tensile properties, the current work reported the feasibility to improve the tensile strength of maltodextrins (MDX) based ODFs by adding an amorphous water insoluble nanofiller, namely polyvinylacetate (PVAc). The possible interactions between components investigated by DSC and ATR-FTIR spectroscopy revealed that MDX and PVAc were immiscible; even if, the presence of plasticizers permitted the homogeneous dispersion of PVAc in the film until the 10% w/w concentration was reached. As a consequence, PVAc nanoparticles was found to be an effective reinforcing agent only at the concentrations of 3 and 5% w/w. In this optimal range, the tensile strength increased at least 1.5 fold and the elastic modulus increased at least 4 times.File | Dimensione | Formato | |
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