Available guidelines on therapeutic drug monitoring of second-generation antipsychotics were designed for adults; therefore, they cannot be transferred as such in pediatric patients, who may have different drug absorption, distribution, metabolism, and elimination. Moreover, available tools that guide dosing in neuropsychiatric pediatric patients are scant, leading to the possibility of reduced efficacy and/or increased risks of toxicity. Here we describe the results of observational therapeutic drug monitoring conducted in three pediatric neuropsychiatry units across Italy in 2012-2014, with the following aims: (1) to describe the distribution of plasma concentrations of second-generation antipsychotics in our pediatric patients and (2) to identify clinical covariates associated with plasma drug levels.
Therapeutic drug monitoring of second-generation antipsychotics in pediatric patients : an observational study in real-life settings / M. Pozzi, D. Cattaneo, S. Baldelli, S. Fucile, A. Capuano, C. Bravaccio, L. Sportiello, S. Bertella, F. Auricchio, R. Bernardini, C. Ferrajolo, G. Guastella, E. Mani, C. Carnovale, S. Pisano, C. Rafaniello, M.P. Riccio, R. Rizzo, M.G. Scuderi, S. Sperandeo, L. Villa, A. Pascotto, M. Molteni, F. Rossi, S. Radice, E. Clementi. - In: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0031-6970. - 72:3(2016 Mar 01), pp. 285-293.
|Titolo:||Therapeutic drug monitoring of second-generation antipsychotics in pediatric patients : an observational study in real-life settings|
|Parole Chiave:||Aripiprazole; Pharmacokinetics; Risperidone; Second-generation antipsychotics; Therapeutic drug monitoring|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1-mar-2016|
|Data ahead of print / Data di stampa:||28-nov-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00228-015-1982-0|
|Appare nelle tipologie:||01 - Articolo su periodico|