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EnglishSummary: This study aimed to evaluate the prevalence and the relationship of sleep breathing disorders (SBDs) and laryngeal motility alterations in patients with drug-resistant epilepsy after vagus nerve stimulator (VNS) implantation. Twenty-three consecutive patients with medically refractory epilepsy underwent out-of-center sleep testing before and after VNS implantation. Eighteen eligible subjects underwent endoscopic laryngeal examination post-VNS implantation. Statistical analysis was carried out to assess an association between laryngeal motility alterations and the onset/worsening of SBDs. After VNS implantation, 11 patients showed a new-onset mild/moderate SBD. Half of the patients already affected by obstructive sleep apnea (OSA) showed worsening of SBD. All of the patients with a new-onset OSA had a laryngeal pattern with left vocal cord adduction (LVCA) during VNS stimulation. The association between VNS-induced LVCA and SBD was statistically significant. This study suggests an association between VNS and SBD, hinting to a pivotal role of laryngeal motility alterations. The relationship between SBD and VNS-induced LVCA supports the need to routinely investigate sleep respiratory and laryngeal motility patterns before and after VNS implantation.
Laryngeal motility alteration : a missing link between sleep apnea and vagus nerve stimulation for epilepsy / E. Zambrelli, A.M. Saibene, F. Furia, V. Chiesa, A. Vignoli, C. Pipolo, G. Felisati, M.P. Canevini. - In: EPILEPSIA. - ISSN 0013-9580. - 57:1(2016 Jan), pp. e24-e27.
| Titolo: | Laryngeal motility alteration : a missing link between sleep apnea and vagus nerve stimulation for epilepsy | |
| Autori: | SAIBENE, ALBERTO MARIA (Secondo) FELISATI, GIOVANNI (Penultimo) CANEVINI, MARIA PAOLA (Ultimo) | |
| Parole Chiave: | Drug-resistant epilepsy; Sleep breathing disorders; Vocal cord dysfunction; Neurology (clinical); Neurology | |
| Settore Scientifico Disciplinare: | Settore MED/26 - Neurologia Settore MED/31 - Otorinolaringoiatria Settore MED/39 - Neuropsichiatria Infantile | |
| Data di pubblicazione: | gen-2016 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Data ahead of print / Data di stampa: | 20-nov-2015 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/epi.13252 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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| Zambrelli_et_al-2016-Epilepsia.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
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