Comparisons of draft genome sequences of three geographically distinct isolates of Fusarium fujikuroi with two recently published genome sequences from the same species suggest diverse profiles of secondary metabolite production within F. fujikuroi. Species- and lineage-specific genes, many of which appear to exhibit expression profiles that are consistent with roles in host-pathogen interactions and adaptation to environmental changes, are concentrated in subtelomeric regions. These genomic compartments also exhibit distinct gene densities and compositional characteristics with respect to other genomic partitions, and likely play a role in the generation of molecular diversity. Our data provide additional evidence that gene duplication, divergence, and differential loss play important roles in F. fujikuroi genome evolution and suggest that hundreds of lineage-specific genes might have been acquired through horizontal gene transfer.
Genome Sequencing of Multiple Isolates Highlights Subtelomeric Genomic Diversity within Fusarium fujikuroi / M. Chiara, F. Fanelli, G. Mulè, A.F. Logrieco, G. Pesole, J.F. Leslie, D.S. Horner, C. Toomajian. - In: GENOME BIOLOGY AND EVOLUTION. - ISSN 1759-6653. - 7:11(2015), pp. 3062-3069.
|Titolo:||Genome Sequencing of Multiple Isolates Highlights Subtelomeric Genomic Diversity within Fusarium fujikuroi|
CHIARA, MATTEO (Primo)
HORNER, DAVID STEPHEN (Penultimo)
|Parole Chiave:||comparative genomics; mycotoxin; secondary metabolites|
|Settore Scientifico Disciplinare:||Settore BIO/11 - Biologia Molecolare|
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/gbe/evv198|
|Appare nelle tipologie:||01 - Articolo su periodico|