Published studies, taken together, suggest the existence of a single canine lymphoma entity, with a small clear cell appearance by cytological evaluation, a histopathological T-zone pattern and an aberrant CD45-negative T-cell phenotype, mostly characterized by long-term survival. We describe clinical presentation and outcome in a retrospective case series of canine small clear cell/T-zone lymphoma. Despite the reported predisposition of Golden retriever, this breed was not represented in our case series. Most dogs presented with stage V disease, whereas only few had clinical signs or peripheral cytopenias. Blood was almost always more infiltrated than bone marrow. Median survival confirmed the favourable prognosis described in literature, but a few dogs died within a short time. Also, a subgroup of dogs developed second malignancies, eventually leading to death. We did not investigate possible prognostic factors because of the wide variety in treatments, and further studies are needed to identify high-risk animals.
Canine small clear cell/T-zone lymphoma: clinical presentation and outcome in a retrospective case series / V. Martini, L. Marconato, A. Poggi, F. Riondato, L. Aresu, M. Cozzi, S. Comazzi. - In: VETERINARY AND COMPARATIVE ONCOLOGY. - ISSN 1476-5810. - 14:suppl. 1(2016 Aug), pp. 117-126.
|Titolo:||Canine small clear cell/T-zone lymphoma: clinical presentation and outcome in a retrospective case series|
MARTINI, VALERIA (Corresponding)
COZZI, MARZIA (Penultimo)
COMAZZI, STEFANO (Ultimo)
|Parole Chiave:||CD45-negative; Clinical presentation; Lymphoma; Outcome; Small clear cell; T-zone|
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
|Data di pubblicazione:||ago-2016|
|Data ahead of print / Data di stampa:||3-giu-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/vco.12155|
|Appare nelle tipologie:||01 - Articolo su periodico|
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|T zone VCO ns 2015.pdf||Publisher's version/PDF||Open Access Visualizza/Apri|
|Canine small clear cell 2015 manuscript.pdf||Post-print, accepted manuscript ecc. (versione accettata dall'editore)||Open Access Visualizza/Apri|
|vco.12155.pdf||Publisher's version/PDF||Open Access Visualizza/Apri|