Cyclopamine- and paclitaxel-containing hetero-nanoparticles generated by self-assembly show combined efficacy in the treatment of three different cancer cell lines. The use of ternary combination with the addition of a dye-squalene conjugate secured the obtainment of fluorescent nanoparticles that permitted the observation of the cellular internalization by confocal microscopy and super-resolution dSTORM (direct stochastic optical reconstruction microscopy).

Cyclopamine-paclitaxel-containing nanoparticles : internalization in cells detected by confocal and super-resolution microscopy / G. Fumagalli, D. Mazza, M.S. Christodoulou, G. Damia, F. Ricci, D. Perdicchia, B. Stella, F. Dosio, P.A. Sotiropoulou, D. Passarella. - In: CHEMPLUSCHEM. - ISSN 2192-6506. - 80:9(2015), pp. 1380-1383.

Cyclopamine-paclitaxel-containing nanoparticles : internalization in cells detected by confocal and super-resolution microscopy

G. Fumagalli
;
M.S. Christodoulou;D. Perdicchia;D. Passarella
Ultimo
2015

Abstract

Cyclopamine- and paclitaxel-containing hetero-nanoparticles generated by self-assembly show combined efficacy in the treatment of three different cancer cell lines. The use of ternary combination with the addition of a dye-squalene conjugate secured the obtainment of fluorescent nanoparticles that permitted the observation of the cellular internalization by confocal microscopy and super-resolution dSTORM (direct stochastic optical reconstruction microscopy).
cancer stem cells; cyclopamine; nanoparticles; paclitaxel; chemistry (all)
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/325978
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