Cyclopamine- and paclitaxel-containing hetero-nanoparticles generated by self-assembly show combined efficacy in the treatment of three different cancer cell lines. The use of ternary combination with the addition of a dye-squalene conjugate secured the obtainment of fluorescent nanoparticles that permitted the observation of the cellular internalization by confocal microscopy and super-resolution dSTORM (direct stochastic optical reconstruction microscopy).
Cyclopamine-paclitaxel-containing nanoparticles : internalization in cells detected by confocal and super-resolution microscopy / G. Fumagalli, D. Mazza, M.S. Christodoulou, G. Damia, F. Ricci, D. Perdicchia, B. Stella, F. Dosio, P.A. Sotiropoulou, D. Passarella. - In: CHEMPLUSCHEM. - ISSN 2192-6506. - 80:9(2015), pp. 1380-1383.
Titolo: | Cyclopamine-paclitaxel-containing nanoparticles : internalization in cells detected by confocal and super-resolution microscopy |
Autori: | PASSARELLA, DANIELE (Ultimo) |
Parole Chiave: | cancer stem cells; cyclopamine; nanoparticles; paclitaxel; chemistry (all) |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica Settore CHIM/08 - Chimica Farmaceutica |
Data di pubblicazione: | 2015 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/cplu.201500156 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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