Micronutrients in a neurodegenerative disorder such as Amyotrophic Lateral Sclerosis

This PhD thesis research project is aimed at investigating the role of micronutrients in Amyotrophic Lateral Scelrosis. Their levels will be correlated with the disease status to evaluate how micronutrients and their regulatory pathways could influence the manifestation and the difference of clinical signs of disease in pre-symptomatic subjects thus explaining the wide phenotypic spectrum of disease. This will be performed through different approaches: clinical, biochemical and genetic in order to obtain a nutritional outcome. This could help to elucidate the role of micronutrients and its metabolism in the pathogenesis and/or in the progression of ALS.