This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5 Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change= 0.93 +/- 0.62; Wilcoxon: p= 0.0002, n= 13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface. (c) 2006 Elsevier Inc. All rights reserved.
Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease / A. PRIORI, G. ARDOLINO, S. MARCEGLIA, S. MRAKIC-SPOSTA, M. LOCATELLI, F. TAMMA, L. ROSSI, G. FOFFANI. - In: BRAIN RESEARCH BULLETIN. - ISSN 0361-9230. - 71:1-3(2006), pp. 149-154.
Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease
A. PRIORI;M. LOCATELLI;
2006
Abstract
This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5 Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change= 0.93 +/- 0.62; Wilcoxon: p= 0.0002, n= 13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface. (c) 2006 Elsevier Inc. All rights reserved.
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