Prevalence of metabolic syndrome is increasing in the pediatric population. Considering the different existing criteria to define metabolic syndrome, the use of the International Diabetes Federation (IDF) criteria has been suggested in children. Docosahexaenoic acid (DHA) has been associated with beneficial effects on health. The evidence about the relationship of DHA status in blood and components of the metabolic syndrome is unclear. This review discusses the possible association between DHA content in plasma and erythrocytes and components of the metabolic syndrome included in the IDF criteria (obesity, alteration of glucose metabolism, blood lipid profile, and blood pressure) and non-alcoholic fatty liver disease in obese children. The current evidence is inconsistent and no definitive conclusion can be drawn in the pediatric population. Well-designed longitudinal and powered trials need to clarify the possible association between blood DHA status and metabolic syndrome.
Docosahexaenoic acid levels in blood and metabolic syndrome in obese children: is there a link? / C. Lassandro, G. Banderali, G. Radaelli, E. Borghi, F. Moretti, E. Verduci. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 16:8(2015 Aug 21), pp. 19989-20000.
|Titolo:||Docosahexaenoic acid levels in blood and metabolic syndrome in obese children: is there a link?|
LASSANDRO, CARLOTTA (Primo)
MORETTI, FRANCESCA (Penultimo)
VERDUCI, ELVIRA (Ultimo)
|Parole Chiave:||Blood pressure; DHA; Glucose metabolism; Lipid profile; Metabolic syndrome; N-3 LCPUFA; NAFLD; Obesity|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||21-ago-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms160819989|
|Appare nelle tipologie:||01 - Articolo su periodico|