Motivated by the antimalarial properties observed in organic peroxides, an extensive series of glycosyl hydroperoxides was prepared with the aim of identifying new bioactive molecules. Selected compounds were tested against a Plasmodium falciparum culture (chloroquine-susceptible strain D10 and chloroquine-resistant strain W2). Screening results indicated that the factors critical for antimalarial activity were the presence of a hydroperoxide moiety and solubility in water at pH 5.0. Moreover, the ability to inhibit β-hematin formation in vitro has been evaluated (BHIA Assay).
|Titolo:||Glycosyl hydroperoxides: a new class of potential antimalarial agents|
|Parole Chiave:||Hydroperoxides; Antimalarial compounds; Glycosides|
|Settore Scientifico Disciplinare:||Settore MED/07 - Microbiologia e Microbiologia Clinica|
Settore MED/04 - Patologia Generale
|Data di pubblicazione:||1-lug-2015|
|Digital Object Identifier (DOI):||10.1016/j.bmc.2015.05.009|
|Appare nelle tipologie:||01 - Articolo su periodico|