Use of peripheral blood- or bone marrow-derived progenitors for ischemic heart repair is a feasible option to induce neo-vascularization in ischemic tissues. These cells, named Endothelial Progenitors Cells (EPCs), have been extensively characterized phenotypically and functionally. The clinical efficacy of cardiac repair by EPCs cells remains, however, limited, due to cell autonomous defects as a consequence of risk factors. The devise of "enhancement" strategies has been therefore sought to improve repair ability of these cells and increase the clinical benefit.
|Titolo:||Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells|
|Parole Chiave:||Clone Cells; Animals; Cardiotonic Agents; Histone Deacetylases; Wound Healing; Humans; Mice; Cell Proliferation; Valproic Acid; Antigens, CD34; Phenotype; Acetylation; Gene Expression Profiling; Fetal Blood; Regeneration; Flow Cytometry; Stem Cells; Cluster Analysis; Histone Deacetylase Inhibitors; Biological Markers|
|Settore Scientifico Disciplinare:||Settore MED/23 - Chirurgia Cardiaca|
Settore BIO/11 - Biologia Molecolare
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||10.1371/journal.pone.0022158|
|Appare nelle tipologie:||01 - Articolo su periodico|