In the present review we summarize observations to date supporting the concept that neuroactive steroids are synthesized in the peripheral nervous system, regulate the physiology of peripheral nerves and exert notable neuroprotective actions. Indeed, neuroactive steroids have been recently proposed as therapies for different types of peripheral neuropathy, like for instance those occurring during aging, chemotherapy, physical injury and diabetes. Moreover, pharmacological tools able to increase the synthesis of neuroactive steroids might represent new interesting therapeutic strategy to be applied in case of peripheral neuropathy.

Neuroactive steroids and the peripheral nervous system : an update / S. Giatti, S. Romano, M. Pesaresi, G. Cermenati, N. Mitro, D. Caruso, M.J. Tetel, L.M. Garcia Segura, R.C. Melcangi. - In: STEROIDS. - ISSN 0039-128X. - 103(2015), pp. 23-30.

Neuroactive steroids and the peripheral nervous system : an update

S. Giatti
;
S. Romano
Secondo
;
M. Pesaresi;G. Cermenati;N. Mitro;D. Caruso;R.C. Melcangi
2015

Abstract

In the present review we summarize observations to date supporting the concept that neuroactive steroids are synthesized in the peripheral nervous system, regulate the physiology of peripheral nerves and exert notable neuroprotective actions. Indeed, neuroactive steroids have been recently proposed as therapies for different types of peripheral neuropathy, like for instance those occurring during aging, chemotherapy, physical injury and diabetes. Moreover, pharmacological tools able to increase the synthesis of neuroactive steroids might represent new interesting therapeutic strategy to be applied in case of peripheral neuropathy.
Metabolism; Neuroprotection; Peripheral neuropathy; Progesterone; Steroidogenesis; Testosterone; Biochemistry; Clinical Biochemistry; Endocrinology; Molecular Biology; Organic Chemistry; Pharmacology
Settore BIO/10 - Biochimica
Settore MED/13 - Endocrinologia
2015
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/296372
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