Background: In 2001 Liou published a 5-year survival model using CFF Registry data. Aims: To evaluate its validity in predicting survival in Italian CF patients. Methods: In a retrospective study on 945 patients, the 9 variables selected by Liou were analyzed, vital status on December 2008 recorded and observed and expected deaths compared. To develop a new model, patients were randomly divided into a derivation (n = 475) and a validation sample (n = 470). Results: A significant difference was found between observed and expected deaths based on Liou's model (62 vs 94), with a 34% reduction in mortality (p < 0.05). A new model (based on FEV1, Staphylococcus aureus and Burkholderia cepacia complex infection, number of pulmonary exacerbations/year) was generated, that correctly predicted survival in the validation sample (31 observed vs 29 expected deaths, p = 0.660). Conclusions: The Liou model did not adequately predict 5-year survival in our CF population that, compared to the one in which it was originally tested, could benefit from 10. years of improvement in treatments and practice patterns. A new generated model, based on only four variables, was more accurate in predicting 5-year survival in Italian CF patients.
|Titolo:||Validation of a predictive survival model in Italian patients with cystic fibrosis|
COLOMBO, CARLA (Corresponding)
|Parole Chiave:||Cystic fibrosis; Survival models; Adolescent; Chi-Square Distribution; Cystic Fibrosis; Female; Forced Expiratory Volume; Humans; Logistic Models; Male; Prognosis; Pseudomonas Infections; Pseudomonas aeruginosa; Survival Analysis; Young Adult; Pulmonary and Respiratory Medicine; Pediatrics, Perinatology and Child Health|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||10.1016/j.jcf.2011.08.007|
|Appare nelle tipologie:||01 - Articolo su periodico|