The importance of the choice of scaffold material for bone regeneration, and the need of new materials and newly formulated scaffolds to improve cell adhesion and accelerate tissue regeneration process are little exploited fields. We report the synthesis and characterization of biodegradable, bioresorbable scaffolds based on polylactic acid (PLA) that can act as temporary extracellular matrix and bears surface modification with adhesive biomolecules. Bioinspired polyphenols have been selected as adhesive biomolecules because they possess biological functions relevant to tissue healing,1 with respect to tissue regeneration, these molecules can stimulate the differentiation of osteoblasts in the non-cytotoxic concentration range. We describe the preparation of specifically architected PLAs, bearing suitable nanocavities to include a synthesized polyphenol, like polytyrosol or polyCAME,2 as osteogenic promoter to stimulate the differentiation of osteoblasts, and improve cell growth. PLA 3D-scaffolds were prepared through the elimination of the solvent from the frozen polymer/polyphenol mixture and the polyphenol incorporation (3 to 10%) was measured through UV analyses. The composites show no toxicity, enhancement of ALP activity and packing efficiency of the osteoblasts compared to the scaffold without the polyphenol.
|Titolo:||Polyphenol modified polylactic sponges with improved osteogenic properties|
|Data di pubblicazione:||giu-2015|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
Settore CHIM/04 - Chimica Industriale
|Citazione:||Polyphenol modified polylactic sponges with improved osteogenic properties / S. Antenucci, H. Farina, M. Ortenzi, L. Panzella, A. Napolitano, B. Burlando, E. Ranzato, S. Martinotti, L. Verotta. ((Intervento presentato al 9. convegno World Congress on Polyphenols Applications. tenutosi a St Julian nel 2015.|
|Appare nelle tipologie:||14 - Intervento a convegno non pubblicato|