The purpose of this study was a comparison between new and worn siloxane-hydrogel contact lenses in terms of microscopic structure, surface morphology, and loading of hyaluronan. The analyses were performed by scanning electron microscopy, with the support of the freeze-drying technique, and by fluorescence confocal microscopy. Along the depth profile of new lenses, a thin porous top layer was observed, which corresponds to the region of hyaluronan penetration inside well-defined channels. The time evolution was followed from one day to two weeks of daily wear, when a completely different scenario was found. Clear experimental evidence of a buggy surface was observed with several crests and regions of swelling, which could be filled by the hyaluronan solution. The modifications are attributed to the progressive relaxation of the structure of the polymeric network.
Wear effects on microscopic morphology and hyaluronan uptake in siloxane-hydrogel contact lenses / S. Tavazzi, M. Tonveronachi, M. Fagnola, F. Cozza, L. Ferraro, A. Borghesi, M. Ascagni, S. Farris. - In: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B, APPLIED BIOMATERIALS.. - ISSN 1552-4973. - 103:5(2015 Jul), pp. 1092-1098.
|Titolo:||Wear effects on microscopic morphology and hyaluronan uptake in siloxane-hydrogel contact lenses|
ASCAGNI, MIRIAM (Penultimo)
FARRIS, STEFANO (Ultimo)
|Parole Chiave:||contact lens; siloxane-hydrogel; freeze-drying; scanning electron microscopy; hyaluronan|
|Settore Scientifico Disciplinare:||Settore CHIM/05 - Scienza e Tecnologia dei Materiali Polimerici|
Settore AGR/15 - Scienze e Tecnologie Alimentari
|Data di pubblicazione:||lug-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jbm.b.33278|
|Appare nelle tipologie:||01 - Articolo su periodico|