Many in-vitro and in-vivo studies confirmed that hyaluronic acid (HA) is closely involved in fibroblast proliferation, enhanced formation of granulation tissue and even in keratinocyte proliferation and migration during wound healing process.1 The aim was to explore the application of available in commerce HA-containing wound dressing on naturally occurring canine skin open wounds healed by second intention. In addition to wound area the progress of healing was also monitored using two well-recognized wound assessment scales of human medicine that quantitatively described the status of salient physiologic wound characteristics. Twelve canine spontaneous cutaneous open wounds healed completely by only second intention were prospectively enrolled. All wounds were treated using a range of wound dressing containing HA from admission to complete re-epithelialization of the wound assessed by clinician. Because wound healing is a dynamic process, the choice of which HA-containing dressing had to be used was modified during healing phases according to salient physiologic wound characteristics and to manufacturer's instruction. At all clinical control and/or bandage change, for each wound, the wound area and the scale scoring assessments were performed and recorded in double blinded modality by two clinicians with same experience in wound healing assessment. An agreement between two clinicians' evaluations in the application of both scoring systems was also investigated.Based on wound etiology, 7 were traumatic, 2 were primary closure complication and 3 were excised wounds. At admission, the mean and median values of wound area were 72.8 and 32 cm2, respectively. After debridement an increased wound size was obtained while an improvement was determined by both scale score systems. The median number of return to clinic was 5 times, respectively. The mean and median time to complete wound healing were 42.3 and 34.5 days, respectively. The mean wound area at day 7 was 90.4%, at day 14 was 47.7%, at day 21 was 22.4% and at day 28 was 14.8% of the original size. All products were well tolerated. The agreement between the two operators was considered high using both wound healing assessment tools. Even if no control group was available, considering the short median time of complete epithelialization HA- containing dressing could be consider a possible wound treatment to enhance healing of open wounds in dogs. The assessment of wound parameters in addition to wound area could be useful especially in the earlier healing period and also to direct clinical decision-making. Further studies are needed to confirm these results and to compare HA-containing dressing with other wound therapies.

Preliminary clinical experience on hyaluronic acid to enhance the healing of canine spontaneous open wounds: an observational study on 12 cases / R. Ferrari, P. Boracchi, S. Romussi, G. Ravasio, D. Stefanello. ((Intervento presentato al 68. convegno SISVET tenutosi a Pisa nel 2014.

Preliminary clinical experience on hyaluronic acid to enhance the healing of canine spontaneous open wounds: an observational study on 12 cases

R. Ferrari
Primo
;
P. Boracchi
Secondo
;
S. Romussi;G. Ravasio
Penultimo
;
D. Stefanello
Ultimo
2014

Abstract

Many in-vitro and in-vivo studies confirmed that hyaluronic acid (HA) is closely involved in fibroblast proliferation, enhanced formation of granulation tissue and even in keratinocyte proliferation and migration during wound healing process.1 The aim was to explore the application of available in commerce HA-containing wound dressing on naturally occurring canine skin open wounds healed by second intention. In addition to wound area the progress of healing was also monitored using two well-recognized wound assessment scales of human medicine that quantitatively described the status of salient physiologic wound characteristics. Twelve canine spontaneous cutaneous open wounds healed completely by only second intention were prospectively enrolled. All wounds were treated using a range of wound dressing containing HA from admission to complete re-epithelialization of the wound assessed by clinician. Because wound healing is a dynamic process, the choice of which HA-containing dressing had to be used was modified during healing phases according to salient physiologic wound characteristics and to manufacturer's instruction. At all clinical control and/or bandage change, for each wound, the wound area and the scale scoring assessments were performed and recorded in double blinded modality by two clinicians with same experience in wound healing assessment. An agreement between two clinicians' evaluations in the application of both scoring systems was also investigated.Based on wound etiology, 7 were traumatic, 2 were primary closure complication and 3 were excised wounds. At admission, the mean and median values of wound area were 72.8 and 32 cm2, respectively. After debridement an increased wound size was obtained while an improvement was determined by both scale score systems. The median number of return to clinic was 5 times, respectively. The mean and median time to complete wound healing were 42.3 and 34.5 days, respectively. The mean wound area at day 7 was 90.4%, at day 14 was 47.7%, at day 21 was 22.4% and at day 28 was 14.8% of the original size. All products were well tolerated. The agreement between the two operators was considered high using both wound healing assessment tools. Even if no control group was available, considering the short median time of complete epithelialization HA- containing dressing could be consider a possible wound treatment to enhance healing of open wounds in dogs. The assessment of wound parameters in addition to wound area could be useful especially in the earlier healing period and also to direct clinical decision-making. Further studies are needed to confirm these results and to compare HA-containing dressing with other wound therapies.
17-giu-2014
hyaluronan; second intention; dog
Settore VET/09 - Clinica Chirurgica Veterinaria
Preliminary clinical experience on hyaluronic acid to enhance the healing of canine spontaneous open wounds: an observational study on 12 cases / R. Ferrari, P. Boracchi, S. Romussi, G. Ravasio, D. Stefanello. ((Intervento presentato al 68. convegno SISVET tenutosi a Pisa nel 2014.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/285645
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