A bicyclic scaffold derived from the natural monosaccharide d-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-3' position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.
|Titolo:||Bicyclic carbohydrate-derived scaffolds for combinatorial libraries|
|Autori interni:||GENNARI, CESARE MARIO ARTURO (Penultimo)|
|Parole Chiave:||Antitumor; Carbohydrate; Scaffolds; Solid phase organic chemistry|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||2006|
|Digital Object Identifier (DOI):||10.1016/j.bmc.2005.12.055|
|Appare nelle tipologie:||01 - Articolo su periodico|