A bicyclic scaffold derived from the natural monosaccharide d-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-3' position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.
Bicyclic carbohydrate-derived scaffolds for combinatorial libraries / G. Cervi, F. Peri, C. Battistini, C. Gennari, F. Nicotra. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 14:10(2006), pp. 3349-3367.
Bicyclic carbohydrate-derived scaffolds for combinatorial libraries
C. GennariPenultimo
;
2006
Abstract
A bicyclic scaffold derived from the natural monosaccharide d-glucose, and possessing several diversity sites, was linked to various resins through the primary (C-6) hydroxyl and decorated on the solid phase: the hydroxyl group at C-4 was functionalized as ester, ether, and carbamate, the amino group in the second cycle (C-3' position) was functionalized as amide, sulfonamide, and ureido- and thioureido-derivatives. The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines.
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