Increasing efforts have recently been spent onto the accomplishment of oral colon targeting. Indeed, this has been related to a number of local as well as systemic highly interesting applications, such as a more effective and tolerable therapy of inflammatory bowel disease (IBD), the pharmacological prevention of colorectal adenocarcinoma, and a possible improvement in the oral bioavailability of peptide and protein drugs. For the purpose of colon targeting, a variety of delivery technologies have been described, which rely on typical variation patterns shown by selected physiological parameters throughout the gastrointestinal tract. In particular, this article is focused on time-based formulation approaches that exploit the relative consistency in the small intestinal transit time (SITT) of dosage forms
Oral Colon Delivery: rationale and time-based drug design strategy / A. Gazzaniga, A. Maroni, A. Foppoli, L. Palugan. - In: DISCOVERY MEDICINE. - ISSN 1539-6509. - 6:36(2006 Dec), pp. 223-228.
Oral Colon Delivery: rationale and time-based drug design strategy
A. Gazzaniga
Primo
;A. MaroniSecondo
;A. FoppoliPenultimo
;L. PaluganUltimo
2006
Abstract
Increasing efforts have recently been spent onto the accomplishment of oral colon targeting. Indeed, this has been related to a number of local as well as systemic highly interesting applications, such as a more effective and tolerable therapy of inflammatory bowel disease (IBD), the pharmacological prevention of colorectal adenocarcinoma, and a possible improvement in the oral bioavailability of peptide and protein drugs. For the purpose of colon targeting, a variety of delivery technologies have been described, which rely on typical variation patterns shown by selected physiological parameters throughout the gastrointestinal tract. In particular, this article is focused on time-based formulation approaches that exploit the relative consistency in the small intestinal transit time (SITT) of dosage formsFile | Dimensione | Formato | |
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