We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients.
Titolo: | Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions |
Autori: | |
Parole Chiave: | azabicycloalkane amino-acids; adherens junctions; cell-adhesion; antagonists; dimerization; specificity; mechanism; peptide |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | 2015 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | 10.1039/C4OB02538E |
Appare nelle tipologie: | 01 - Articolo su periodico |
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