C-reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, the prototype of which is PTX3, are expressed in a variety of tissues. PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to TLR engagement and inflammatory cytokines. PTX3 acts as a functional ancestor of antibodies, recognizing microbes, activating complement, facilitating pathogen recognition by phagocytes, hence playing a non-redundant role in resistance against selected pathogens, in particular in the lung. Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition and female fertility.
|Titolo:||Pentraxins in innate immunity and inflammation|
|Autori interni:||MANTOVANI, ALBERTO (Ultimo)|
VELIZ RODRIGUEZ, TANIA (Penultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2006|
|Appare nelle tipologie:||01 - Articolo su periodico|