The preparation of fluorescent nanoparticles containing squalenoyl-paclitaxel and a squalene-based fluorescein derivative is presented. The formation of self-assembled heteronanoparticles was confirmed by using the quasielastic light scattering (QELS) technique. The internalization in A549 human lung carcinoma cells was verified by microscopy analysis. Finally, paclitaxel in nanoassemblies maintains its ability to target microtubules.
Self-Assembled squalene-based fluorescent heteronanoparticles / S. Borrelli, D. Cartelli, F. Secundo, G. Fumagalli, M. Christodoulou, A. Borroni, D. Perdicchia, F. Dosio, P. Milla, G. Cappelletti, D. Passarella. - In: CHEMPLUSCHEM. - ISSN 2192-6506. - 80:1(2015 Jan), pp. 47-49. [10.1002/cplu.201402239]
Self-Assembled squalene-based fluorescent heteronanoparticles
S. Borrelli;D. Cartelli;G. Fumagalli;M. Christodoulou;D. Perdicchia;G. Cappelletti;D. Passarella
2015
Abstract
The preparation of fluorescent nanoparticles containing squalenoyl-paclitaxel and a squalene-based fluorescein derivative is presented. The formation of self-assembled heteronanoparticles was confirmed by using the quasielastic light scattering (QELS) technique. The internalization in A549 human lung carcinoma cells was verified by microscopy analysis. Finally, paclitaxel in nanoassemblies maintains its ability to target microtubules.
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