The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.

Different Aaenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease / C. Gussago, B. Arosio, M. Casati, E. Ferri, F. Gualandris, E. Tedone, P. Nicolini, P.D. Rossi, C. Abbate, D. Mari. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 40:1(2014), pp. 45-49. [10.3233/JAD-131652]

Different Aaenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease

C. Gussago;B. Arosio;M. Casati;E. Ferri;E. Tedone;P. Nicolini;C. Abbate;D. Mari
2014

Abstract

The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.
adenosine receptors; Alzheimer's disease; biomarker; vascular dementia
Settore MED/09 - Medicina Interna
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/251656
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