Despite epidemiological findings showing increased air pollution related cardiovascular diseases (CVD), the knowledge of the involved molecular mechanisms remains moderate or weak. Particulate matter (PM) produces a local strong inflammatory reaction in the pulmonary environment but there is no final evidence that PM physically enters and deposits in blood vessels. Extracellular vesicles (EVs) and their miRNA cargo might be the ideal candidate to mediate the effects of PM, since they could be potentially produced by the respiratory system, reach the systemic circulation and lead to the development of cardiovascular effects.The SPHERE ("Susceptibility to Particle Health Effects, miRNAs and Exosomes") project was granted by ERC-2011-StG 282413, to examine possible molecular mechanisms underlying the effects of PM exposure in relation to health outcomes.
Susceptibility to particle health effects, miRNA and exosomes : rationale and study protocol of the SPHERE study / V. Bollati, S. Iodice, C. Favero, L. Angelici, B. Albetti, R. Cacace, L. Cantone, M. Carugno, T. Cavalleri, B. De Giorgio, L. Dioni, S. Fustinoni, M. Hoxha, B. Marinelli, V. Motta, L. Patrini, L. Pergoli, L. Riboldi, G. Rizzo, F. Rota, S. Sucato, L. Tarantini, A.S. Tirelli, L. Vigna, P. Bertazzi, A.C. Pesatori. - In: BMC PUBLIC HEALTH. - ISSN 1471-2458. - 14:1(2014 Nov 04), pp. 1137.1-1137.13.
|Titolo:||Susceptibility to particle health effects, miRNA and exosomes : rationale and study protocol of the SPHERE study|
|Parole Chiave:||particle health effects and miRNA|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Progetto:||Susceptibily to Particle Healt Effects, miRNAs and Exosomes|
|Data di pubblicazione:||4-nov-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1186/1471-2458-14-1137|
|Appare nelle tipologie:||01 - Articolo su periodico|