A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has been established. In this issue, Chien et al. (2006) show that the RalB GTPase regulates the IKK family member TBK1, providing an unexpected link between the signaling pathways that promote inflammation and cancer. In tumor cells the RalB/TBK1 pathway inhibits apoptosis and in nontumorigenic cells it stimulates an innate immune response.
|Titolo:||RalB signaling : a bridge between inflammation and cancer|
|Autori interni:||MANTOVANI, ALBERTO|
|Parole Chiave:||Inflammation; Neoplasm; Signal transduction (RalB signaling bridges between inflammation and cancer); G proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (RalB; RalB signaling bridges between inflammation and cancer)|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||6-ott-2006|
|Digital Object Identifier (DOI):||10.1016/j.cell.2006.09.019|
|Appare nelle tipologie:||01 - Articolo su periodico|