Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.
|Titolo:||Pentraxins as a key component of innate immunity|
MANTOVANI, ALBERTO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||feb-2006|
|Digital Object Identifier (DOI):||10.1016/j.coi.2005.11.009|
|Appare nelle tipologie:||01 - Articolo su periodico|