Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.
Pentraxins as a key component of innate immunity / B. Bottazzi, C. Garlanda, G. Salvatori, P. Jeannin, A. Manfredi, A. Mantovani. - In: CURRENT OPINION IN IMMUNOLOGY. - ISSN 0952-7915. - 18:1(2006 Feb), pp. 10-15.
Pentraxins as a key component of innate immunity
A. MantovaniUltimo
2006
Abstract
Pentraxins are a complex superfamily of multifunctional molecules characterized by a multimeric structure. C-reactive protein and pentraxin 3 (PTX3) are prototypic molecules of the short and long pentraxin family, respectively. PTX3 is conserved in evolution and produced by innate immune cells. Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation.Pubblicazioni consigliate
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