A biocatalyzed reduction of a prochiral bicyclic ketone afforded enantiomerically pure (R)-2-acetylamino-6-hydroxy-4,5,6,7-tetrahydrobenzothiazole, a synthon of the anti-Parkinson (S)-pramipexole and its (R)-isomer, which is currently under investigation for the treatment of amyotrofic lateral sclerosis (ALS)
Baker’s yeast catalyzed preparation of a new enantiomerically pure synthon of (S)-pramipexole and its enantiomer (dexpramipexole) / P. Ferraboschi, S. Ciceri, P. Ciuffreda, M. De Mieri, D. Romano, P. Grisenti. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 25:16-17(2014), pp. 1239-1245. [10.1016/j.tetasy.2014.07.011]
Baker’s yeast catalyzed preparation of a new enantiomerically pure synthon of (S)-pramipexole and its enantiomer (dexpramipexole)
P. FerraboschiPrimo
;S. Ciceri;P. Ciuffreda;D. RomanoPenultimo
;
2014
Abstract
A biocatalyzed reduction of a prochiral bicyclic ketone afforded enantiomerically pure (R)-2-acetylamino-6-hydroxy-4,5,6,7-tetrahydrobenzothiazole, a synthon of the anti-Parkinson (S)-pramipexole and its (R)-isomer, which is currently under investigation for the treatment of amyotrofic lateral sclerosis (ALS)
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