Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokines and targets them to degradation via constitutive ligand-independent internalization. Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and placenta to dampen inflammation in tissues and draining lymph nodes.
The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses / E.M. Borroni, C. Buracchi, Y.M. de la Torre, E. Galliera, A. Vecchi, R. Bonecchi, A. Mantovani, M. Locati. - In: BIOCHEMICAL SOCIETY TRANSACTIONS. - ISSN 0300-5127. - 34:6(2006 Dec), pp. 1014-1017. [10.1042/BST0341014]
The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses
E.M. BorroniPrimo
;E. Galliera;R. Bonecchi;A. MantovaniPenultimo
;M. LocatiUltimo
2006
Abstract
Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokines and targets them to degradation via constitutive ligand-independent internalization. Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and placenta to dampen inflammation in tissues and draining lymph nodes.Pubblicazioni consigliate
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