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Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
Defining the role of common variation in the genomic and biological architecture of adult human height / A.R. Wood, T. Esko, J. Yang, S. Vedantam, T.H. Pers, S. Gustafsson, A.Y. Chu, K. Estrada, J. Luan, Z. Kutalik, N. Amin, M.L. Buchkovich, D.C. Croteau Chonka, F.R. Day, Y. Duan, T. Fall, R. Fehrmann, T. Ferreira, A.U. Jackson, J. Karjalainen, K.S. Lo, A.E. Locke, R. Mägi, E. Mihailov, E. Porcu, J.C. Randall, A. Scherag, A.A.E. Vinkhuyzen, H. Westra, T.W. Winkler, T. Workalemahu, J.H. Zhao, D. Absher, E. Albrecht, D. Anderson, J. Baron, M. Beekman, A. Demirkan, G.B. Ehret, B. Feenstra, M.F. Feitosa, K. Fischer, R.M. Fraser, A. Goel, J. Gong, A.E. Justice, S. Kanoni, M.E. Kleber, K. Kristiansson, U. Lim, V. Lotay, J.C. Lui, M. Mangino, I.M. Leach, C. Medina Gomez, M.A. Nalls, D.R. Nyholt, C.D. Palmer, D. Pasko, S. Pechlivanis, I. Prokopenko, J.S. Ried, S. Ripke, D. Shungin, A. Stancáková, R.J. Strawbridge, Y.J. Sung, T. Tanaka, A. Teumer, S. Trompet, S.W. van der Laan, J. van Setten, J.V. Van Vliet Ostaptchouk, Z. Wang, L. Yengo, W. Zhang, U. Afzal, J. Arnlöv, G.M. Arscott, S. Bandinelli, A. Barrett, C. Bellis, A.J. Bennett, C. Berne, M. Blüher, J.L. Bolton, Y. Böttcher, H.A. Boyd, M. Bruinenberg, B.M. Buckley, S. Buyske, I.H. Caspersen, P.S. Chines, R. Clarke, S. Claudi Boehm, M. Cooper, E.W. Daw, P.A. De Jong, J. Deelen, G. Delgado, J.C. Denny, R. Dhonukshe Rutten, M. Dimitriou, A.S.F. Doney, M. Dörr, N. Eklund, E. Eury, L. Folkersen, M.E. Garcia, F. Geller, V. Giedraitis, A.S. Go, H. Grallert, T.B. Grammer, J. Gräßler, H. Grönberg, L.C.P.G.M. de Groot, C.J. Groves, J. Haessler, P. Hall, T. Haller, G. Hallmans, A. Hannemann, C.A. Hartman, M. Hassinen, C. Hayward, N.L. Heard Costa, Q. Helmer, G. Hemani, A.K. Henders, H.L. Hillege, M.A. Hlatky, W. Hoffmann, P. Hoffmann, O. Holmen, J.J. Houwing Duistermaat, T. Illig, A. Isaacs, A.L. James, J. Jeff, B. Johansen, A. Johansson, J. Jolley, T. Juliusdottir, J. Junttila, A.N. Kho, L. Kinnunen, N. Klopp, T. Kocher, W. Kratzer, P. Lichtner, L. Lind, J. Lindström, S. Lobbens, M. Lorentzon, Y. Lu, V. Lyssenko, P.K.E. Magnusson, A. Mahajan, M. Maillard, W.L. Mcardle, C.A. Mckenzie, S. Mclachlan, P.J. Mclaren, C. Menni, S. Merger, L. Milani, A. Moayyeri, K.L. Monda, M.A. Morken, G. Müller, M. Müller Nurasyid, A.W. Musk, N. Narisu, M. Nauck, I.M. Nolte, M.M. Nöthen, L. Oozageer, S. Pilz, N.W. Rayner, F. Renstrom, N.R. Robertson, L.M. Rose, R. Roussel, S. Sanna, H. Scharnagl, S. Scholtens, F.R. Schumacher, H. Schunkert, R.A. Scott, J. Sehmi, T. Seufferlein, J. Shi, K. Silventoinen, J.H. Smit, A.V. Smith, J. Smolonska, A.V. Stanton, K. Stirrups, D.J. Stott, H.M. Stringham, J. Sundström, M.A. Swertz, A. Syvänen, B.O. Tayo, G. Thorleifsson, J.P. Tyrer, S. van Dijk, N.M. van Schoor, N. van der Velde, D. van Heemst, F.V.A. van Oort, S.H. Vermeulen, N. Verweij, J.M. Vonk, L.L. Waite, M. Waldenberger, R. Wennauer, L.R. Wilkens, C. Willenborg, T. Wilsgaard, M.K. Wojczynski, A. Wong, A.F. Wright, Q. Zhang, D. Arveiler, S.J.L. Bakker, J. Beilby, R.N. Bergman, S. Bergmann, R. Biffar, J. Blangero, D.I. Boomsma, S.R. Bornstein, P. Bovet, P. Brambilla, M.J. Brown, H. Campbell, M.J. Caulfield, A. Chakravarti, R. Collins, F.S. Collins, D.C. Crawford, L.A. Cupples, J. Danesh, U. de Faire, H.M. den Ruijter, R. Erbel, J. Erdmann, J.G. Eriksson, M. Farrall, E. Ferrannini, J. Ferrières, I. Ford, N.G. Forouhi, T. Forrester, R.T. Gansevoort, P.V. Gejman, C. Gieger, A. Golay, O. Gottesman, V. Gudnason, U. Gyllensten, D.W. Haas, A.S. Hall, T.B. Harris, A.T. Hattersley, A.C. Heath, C. Hengstenberg, A.A. Hicks, L.A. Hindorff, A.D. Hingorani, A. Hofman, G.K. Hovingh, S.E. Humphries, S.C. Hunt, E. Hypponen, K.B. Jacobs, M. Jarvelin, P. Jousilahti, A.M. Jula, J. Kaprio, J.J.P. Kastelein, M. Kayser, F. Kee, S.M. Keinanen Kiukaanniemi, L.A. Kiemeney, J.S. Kooner, C. Kooperberg, S. Koskinen, P. Kovacs, A.T. Kraja, M. Kumari, J. Kuusisto, T.A. Lakka, C. Langenberg, L. Le Marchand, T. Lehtimäki, S. Lupoli, P.A.F. Madden, S. Männistö, P. Manunta, A. Marette, T.C. Matise, B. Mcknight, T. Meitinger, F.L. Moll, G.W. Montgomery, A.D. Morris, A.P. Morris, J.C. Murray, M. Nelis, C. Ohlsson, A.J. Oldehinkel, K.K. Ong, W.H. Ouwehand, G. Pasterkamp, A. Peters, P.P. Pramstaller, J.F. Price, L. Qi, O.T. Raitakari, T. Rankinen, D.C. Rao, T.K. Rice, M. Ritchie, I. Rudan, V. Salomaa, N.J. Samani, J. Saramies, M.A. Sarzynski, P.E.H. Schwarz, S. Sebert, P. Sever, A.R. Shuldiner, J. Sinisalo, V. Steinthorsdottir, R.P. Stolk, J. Tardif, A. Tönjes, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, P. Amouyel, F.W. Asselbergs, T.L. Assimes, M. Bochud, B.O. Boehm, E. Boerwinkle, E.P. Bottinger, C. Bouchard, S. Cauchi, J.C. Chambers, S.J. Chanock, R.S. Cooper, P.I.W. de Bakker, G. Dedoussis, L. Ferrucci, P.W. Franks, P. Froguel, L.C. Groop, C.A. Haiman, A. Hamsten, M.G. Hayes, J. Hui, D.J. Hunter, K. Hveem, J.W. Jukema, R.C. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Y. Liu, N.G. Martin, W. März, M. Melbye, S. Moebus, P.B. Munroe, I. Njølstad, B.A. Oostra, C.N.A. Palmer, N.L. Pedersen, M. Perola, L. Pérusse, U. Peters, J.E. Powell, C. Power, T. Quertermous, R. Rauramaa, E. Reinmaa, P.M. Ridker, F. Rivadeneira, J.I. Rotter, T.E. Saaristo, D. Saleheen, D. Schlessinger, P.E. Slagboom, H. Snieder, T.D. Spector, K. Strauch, M. Stumvoll, J. Tuomilehto, M. Uusitupa, P. van der Harst, H. Völzke, M. Walker, N.J. Wareham, H. Watkins, H. Wichmann, J.F. Wilson, P. Zanen, P. Deloukas, I.M. Heid, C.M. Lindgren, K.L. Mohlke, E.K. Speliotes, U. Thorsteinsdottir, I. Barroso, C.S. Fox, K.E. North, D.P. Strachan, J.S. Beckmann, S.I. Berndt, M. Boehnke, I.B. Borecki, M.I. Mccarthy, A. Metspalu, K. Stefansson, A.G. Uitterlinden, C.M. van Duijn, L. Franke, C.J. Willer, A.L. Price, G. Lettre, R.J.F. Loos, M.N. Weedon, E. Ingelsson, J.R. O'Connell, G.R. Abecasis, D.I. Chasman, M.E. Goddard, P.M. Visscher, J.N. Hirschhorn, T.M. Frayling. - In: NATURE GENETICS. - ISSN 1061-4036. - 46:11(2014 Nov), pp. 1173-1186. [10.1038/ng.3097]
Defining the role of common variation in the genomic and biological architecture of adult human height
A. R. Wood;T. Esko;J. Yang;S. Vedantam;T. H. Pers;S. Gustafsson;A. Y. Chu;K. Estrada;J. Luan;Z. Kutalik;N. Amin;M. L. Buchkovich;D. C. Croteau Chonka;F. R. Day;Y. Duan;T. Fall;R. Fehrmann;T. Ferreira;A. U. Jackson;J. Karjalainen;K. S. Lo;A. E. Locke;R. Mägi;E. Mihailov;E. Porcu;J. C. Randall;A. Scherag;A. A. E. Vinkhuyzen;H. Westra;T. W. Winkler;T. Workalemahu;J. H. Zhao;D. Absher;E. Albrecht;D. Anderson;J. Baron;M. Beekman;A. Demirkan;G. B. Ehret;B. Feenstra;M. F. Feitosa;K. Fischer;R. M. Fraser;A. Goel;J. Gong;A. E. Justice;S. Kanoni;M. E. Kleber;K. Kristiansson;U. Lim;V. Lotay;J. C. Lui;M. Mangino;I. M. Leach;C. Medina Gomez;M. A. Nalls;D. R. Nyholt;C. D. Palmer;D. Pasko;S. Pechlivanis;I. Prokopenko;J. S. Ried;S. Ripke;D. Shungin;A. Stancáková;R. J. Strawbridge;Y. J. Sung;T. Tanaka;A. Teumer;S. Trompet;S. W. van der Laan;J. van Setten;J. V. Van Vliet Ostaptchouk;Z. Wang;L. Yengo;W. Zhang;U. Afzal;J. Arnlöv;G. M. Arscott;S. Bandinelli;A. Barrett;C. Bellis;A. J. Bennett;C. Berne;M. Blüher;J. L. Bolton;Y. Böttcher;H. A. Boyd;M. Bruinenberg;B. M. Buckley;S. Buyske;I. H. Caspersen;P. S. Chines;R. Clarke;S. Claudi Boehm;M. Cooper;E. W. Daw;P. A. De Jong;J. Deelen;G. Delgado;J. C. Denny;R. Dhonukshe Rutten;M. Dimitriou;A. S. F. Doney;M. Dörr;N. Eklund;E. Eury;L. Folkersen;M. E. Garcia;F. Geller;V. Giedraitis;A. S. Go;H. Grallert;T. B. Grammer;J. Gräßler;H. Grönberg;L. C. P. G. M. de Groot;C. J. Groves;J. Haessler;P. Hall;T. Haller;G. Hallmans;A. Hannemann;C. A. Hartman;M. Hassinen;C. Hayward;N. L. Heard Costa;Q. Helmer;G. Hemani;A. K. Henders;H. L. Hillege;M. A. Hlatky;W. Hoffmann;P. Hoffmann;O. Holmen;J. J. Houwing Duistermaat;T. Illig;A. Isaacs;A. L. James;J. Jeff;B. Johansen;A. Johansson;J. Jolley;T. Juliusdottir;J. Junttila;A. N. Kho;L. Kinnunen;N. Klopp;T. Kocher;W. Kratzer;P. Lichtner;L. Lind;J. Lindström;S. Lobbens;M. Lorentzon;Y. Lu;V. Lyssenko;P. K. E. Magnusson;A. Mahajan;M. Maillard;W. L. McArdle;C. A. McKenzie;S. McLachlan;P. J. McLaren;C. Menni;S. Merger;L. Milani;A. Moayyeri;K. L. Monda;M. A. Morken;G. Müller;M. Müller Nurasyid;A. W. Musk;N. Narisu;M. Nauck;I. M. Nolte;M. M. Nöthen;L. Oozageer;S. Pilz;N. W. Rayner;F. Renstrom;N. R. Robertson;L. M. Rose;R. Roussel;S. Sanna;H. Scharnagl;S. Scholtens;F. R. Schumacher;H. Schunkert;R. A. Scott;J. Sehmi;T. Seufferlein;J. Shi;K. Silventoinen;J. H. Smit;A. V. Smith;J. Smolonska;A. V. Stanton;K. Stirrups;D. J. Stott;H. M. Stringham;J. Sundström;M. A. Swertz;A. Syvänen;B. O. Tayo;G. Thorleifsson;J. P. Tyrer;S. van Dijk;N. M. van Schoor;N. van der Velde;D. van Heemst;F. V. A. van Oort;S. H. Vermeulen;N. Verweij;J. M. Vonk;L. L. Waite;M. Waldenberger;R. Wennauer;L. R. Wilkens;C. Willenborg;T. Wilsgaard;M. K. Wojczynski;A. Wong;A. F. Wright;Q. Zhang;D. Arveiler;S. J. L. Bakker;J. Beilby;R. N. Bergman;S. Bergmann;R. Biffar;J. Blangero;D. I. Boomsma;S. R. Bornstein;P. Bovet;P. Brambilla;M. J. Brown;H. Campbell;M. J. Caulfield;A. Chakravarti;R. Collins;F. S. Collins;D. C. Crawford;L. A. Cupples;J. Danesh;U. de Faire;H. M. den Ruijter;R. Erbel;J. Erdmann;J. G. Eriksson;M. Farrall;E. Ferrannini;J. Ferrières;I. Ford;N. G. Forouhi;T. Forrester;R. T. Gansevoort;P. V. Gejman;C. Gieger;A. Golay;O. Gottesman;V. Gudnason;U. Gyllensten;D. W. Haas;A. S. Hall;T. B. Harris;A. T. Hattersley;A. C. Heath;C. Hengstenberg;A. A. Hicks;L. A. Hindorff;A. D. Hingorani;A. Hofman;G. K. Hovingh;S. E. Humphries;S. C. Hunt;E. Hypponen;K. B. Jacobs;M. Jarvelin;P. Jousilahti;A. M. Jula;J. Kaprio;J. J. P. Kastelein;M. Kayser;F. Kee;S. M. Keinanen Kiukaanniemi;L. A. Kiemeney;J. S. Kooner;C. Kooperberg;S. Koskinen;P. Kovacs;A. T. Kraja;M. Kumari;J. Kuusisto;T. A. Lakka;C. Langenberg;L. Le Marchand;T. Lehtimäki;S. Lupoli;P. A. F. Madden;S. Männistö;P. Manunta;A. Marette;T. C. Matise;B. McKnight;T. Meitinger;F. L. Moll;G. W. Montgomery;A. D. Morris;A. P. Morris;J. C. Murray;M. Nelis;C. Ohlsson;A. J. Oldehinkel;K. K. Ong;W. H. Ouwehand;G. Pasterkamp;A. Peters;P. P. Pramstaller;J. F. Price;L. Qi;O. T. Raitakari;T. Rankinen;D. C. Rao;T. K. Rice;M. Ritchie;I. Rudan;V. Salomaa;N. J. Samani;J. Saramies;M. A. Sarzynski;P. E. H. Schwarz;S. Sebert;P. Sever;A. R. Shuldiner;J. Sinisalo;V. Steinthorsdottir;R. P. Stolk;J. Tardif;A. Tönjes;A. Tremblay;E. Tremoli;J. Virtamo;M. Vohl;P. Amouyel;F. W. Asselbergs;T. L. Assimes;M. Bochud;B. O. Boehm;E. Boerwinkle;E. P. Bottinger;C. Bouchard;S. Cauchi;J. C. Chambers;S. J. Chanock;R. S. Cooper;P. I. W. de Bakker;G. Dedoussis;L. Ferrucci;P. W. Franks;P. Froguel;L. C. Groop;C. A. Haiman;A. Hamsten;M. G. Hayes;J. Hui;D. J. Hunter;K. Hveem;J. W. Jukema;R. C. Kaplan;M. Kivimaki;D. Kuh;M. Laakso;Y. Liu;N. G. Martin;W. März;M. Melbye;S. Moebus;P. B. Munroe;I. Njølstad;B. A. Oostra;C. N. A. Palmer;N. L. Pedersen;M. Perola;L. Pérusse;U. Peters;J. E. Powell;C. Power;T. Quertermous;R. Rauramaa;E. Reinmaa;P. M. Ridker;F. Rivadeneira;J. I. Rotter;T. E. Saaristo;D. Saleheen;D. Schlessinger;P. E. Slagboom;H. Snieder;T. D. Spector;K. Strauch;M. Stumvoll;J. Tuomilehto;M. Uusitupa;P. van der Harst;H. Völzke;M. Walker;N. J. Wareham;H. Watkins;H. Wichmann;J. F. Wilson;P. Zanen;P. Deloukas;I. M. Heid;C. M. Lindgren;K. L. Mohlke;E. K. Speliotes;U. Thorsteinsdottir;I. Barroso;C. S. Fox;K. E. North;D. P. Strachan;J. S. Beckmann;S. I. Berndt;M. Boehnke;I. B. Borecki;M. I. McCarthy;A. Metspalu;K. Stefansson;A. G. Uitterlinden;C. M. van Duijn;L. Franke;C. J. Willer;A. L. Price;G. Lettre;R. J. F. Loos;M. N. Weedon;E. Ingelsson;J. R. O'Connell;G. R. Abecasis;D. I. Chasman;M. E. Goddard;P. M. Visscher;J. N. Hirschhorn;T. M. Frayling
2014
Abstract
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
Defining the role of common variation in the genomic and biological architecture of adult human height / A.R. Wood, T. Esko, J. Yang, S. Vedantam, T.H. Pers, S. Gustafsson, A.Y. Chu, K. Estrada, J. Luan, Z. Kutalik, N. Amin, M.L. Buchkovich, D.C. Croteau Chonka, F.R. Day, Y. Duan, T. Fall, R. Fehrmann, T. Ferreira, A.U. Jackson, J. Karjalainen, K.S. Lo, A.E. Locke, R. Mägi, E. Mihailov, E. Porcu, J.C. Randall, A. Scherag, A.A.E. Vinkhuyzen, H. Westra, T.W. Winkler, T. Workalemahu, J.H. Zhao, D. Absher, E. Albrecht, D. Anderson, J. Baron, M. Beekman, A. Demirkan, G.B. Ehret, B. Feenstra, M.F. Feitosa, K. Fischer, R.M. Fraser, A. Goel, J. Gong, A.E. Justice, S. Kanoni, M.E. Kleber, K. Kristiansson, U. Lim, V. Lotay, J.C. Lui, M. Mangino, I.M. Leach, C. Medina Gomez, M.A. Nalls, D.R. Nyholt, C.D. Palmer, D. Pasko, S. Pechlivanis, I. Prokopenko, J.S. Ried, S. Ripke, D. Shungin, A. Stancáková, R.J. Strawbridge, Y.J. Sung, T. Tanaka, A. Teumer, S. Trompet, S.W. van der Laan, J. van Setten, J.V. Van Vliet Ostaptchouk, Z. Wang, L. Yengo, W. Zhang, U. Afzal, J. Arnlöv, G.M. Arscott, S. Bandinelli, A. Barrett, C. Bellis, A.J. Bennett, C. Berne, M. Blüher, J.L. Bolton, Y. Böttcher, H.A. Boyd, M. Bruinenberg, B.M. Buckley, S. Buyske, I.H. Caspersen, P.S. Chines, R. Clarke, S. Claudi Boehm, M. Cooper, E.W. Daw, P.A. De Jong, J. Deelen, G. Delgado, J.C. Denny, R. Dhonukshe Rutten, M. Dimitriou, A.S.F. Doney, M. Dörr, N. Eklund, E. Eury, L. Folkersen, M.E. Garcia, F. Geller, V. Giedraitis, A.S. Go, H. Grallert, T.B. Grammer, J. Gräßler, H. Grönberg, L.C.P.G.M. de Groot, C.J. Groves, J. Haessler, P. Hall, T. Haller, G. Hallmans, A. Hannemann, C.A. Hartman, M. Hassinen, C. Hayward, N.L. Heard Costa, Q. Helmer, G. Hemani, A.K. Henders, H.L. Hillege, M.A. Hlatky, W. Hoffmann, P. Hoffmann, O. Holmen, J.J. Houwing Duistermaat, T. Illig, A. Isaacs, A.L. James, J. Jeff, B. Johansen, A. Johansson, J. Jolley, T. Juliusdottir, J. Junttila, A.N. Kho, L. Kinnunen, N. Klopp, T. Kocher, W. Kratzer, P. Lichtner, L. Lind, J. Lindström, S. Lobbens, M. Lorentzon, Y. Lu, V. Lyssenko, P.K.E. Magnusson, A. Mahajan, M. Maillard, W.L. Mcardle, C.A. Mckenzie, S. Mclachlan, P.J. Mclaren, C. Menni, S. Merger, L. Milani, A. Moayyeri, K.L. Monda, M.A. Morken, G. Müller, M. Müller Nurasyid, A.W. Musk, N. Narisu, M. Nauck, I.M. Nolte, M.M. Nöthen, L. Oozageer, S. Pilz, N.W. Rayner, F. Renstrom, N.R. Robertson, L.M. Rose, R. Roussel, S. Sanna, H. Scharnagl, S. Scholtens, F.R. Schumacher, H. Schunkert, R.A. Scott, J. Sehmi, T. Seufferlein, J. Shi, K. Silventoinen, J.H. Smit, A.V. Smith, J. Smolonska, A.V. Stanton, K. Stirrups, D.J. Stott, H.M. Stringham, J. Sundström, M.A. Swertz, A. Syvänen, B.O. Tayo, G. Thorleifsson, J.P. Tyrer, S. van Dijk, N.M. van Schoor, N. van der Velde, D. van Heemst, F.V.A. van Oort, S.H. Vermeulen, N. Verweij, J.M. Vonk, L.L. Waite, M. Waldenberger, R. Wennauer, L.R. Wilkens, C. Willenborg, T. Wilsgaard, M.K. Wojczynski, A. Wong, A.F. Wright, Q. Zhang, D. Arveiler, S.J.L. Bakker, J. Beilby, R.N. Bergman, S. Bergmann, R. Biffar, J. Blangero, D.I. Boomsma, S.R. Bornstein, P. Bovet, P. Brambilla, M.J. Brown, H. Campbell, M.J. Caulfield, A. Chakravarti, R. Collins, F.S. Collins, D.C. Crawford, L.A. Cupples, J. Danesh, U. de Faire, H.M. den Ruijter, R. Erbel, J. Erdmann, J.G. Eriksson, M. Farrall, E. Ferrannini, J. Ferrières, I. Ford, N.G. Forouhi, T. Forrester, R.T. Gansevoort, P.V. Gejman, C. Gieger, A. Golay, O. Gottesman, V. Gudnason, U. Gyllensten, D.W. Haas, A.S. Hall, T.B. Harris, A.T. Hattersley, A.C. Heath, C. Hengstenberg, A.A. Hicks, L.A. Hindorff, A.D. Hingorani, A. Hofman, G.K. Hovingh, S.E. Humphries, S.C. Hunt, E. Hypponen, K.B. Jacobs, M. Jarvelin, P. Jousilahti, A.M. Jula, J. Kaprio, J.J.P. Kastelein, M. Kayser, F. Kee, S.M. Keinanen Kiukaanniemi, L.A. Kiemeney, J.S. Kooner, C. Kooperberg, S. Koskinen, P. Kovacs, A.T. Kraja, M. Kumari, J. Kuusisto, T.A. Lakka, C. Langenberg, L. Le Marchand, T. Lehtimäki, S. Lupoli, P.A.F. Madden, S. Männistö, P. Manunta, A. Marette, T.C. Matise, B. Mcknight, T. Meitinger, F.L. Moll, G.W. Montgomery, A.D. Morris, A.P. Morris, J.C. Murray, M. Nelis, C. Ohlsson, A.J. Oldehinkel, K.K. Ong, W.H. Ouwehand, G. Pasterkamp, A. Peters, P.P. Pramstaller, J.F. Price, L. Qi, O.T. Raitakari, T. Rankinen, D.C. Rao, T.K. Rice, M. Ritchie, I. Rudan, V. Salomaa, N.J. Samani, J. Saramies, M.A. Sarzynski, P.E.H. Schwarz, S. Sebert, P. Sever, A.R. Shuldiner, J. Sinisalo, V. Steinthorsdottir, R.P. Stolk, J. Tardif, A. Tönjes, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, P. Amouyel, F.W. Asselbergs, T.L. Assimes, M. Bochud, B.O. Boehm, E. Boerwinkle, E.P. Bottinger, C. Bouchard, S. Cauchi, J.C. Chambers, S.J. Chanock, R.S. Cooper, P.I.W. de Bakker, G. Dedoussis, L. Ferrucci, P.W. Franks, P. Froguel, L.C. Groop, C.A. Haiman, A. Hamsten, M.G. Hayes, J. Hui, D.J. Hunter, K. Hveem, J.W. Jukema, R.C. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Y. Liu, N.G. Martin, W. März, M. Melbye, S. Moebus, P.B. Munroe, I. Njølstad, B.A. Oostra, C.N.A. Palmer, N.L. Pedersen, M. Perola, L. Pérusse, U. Peters, J.E. Powell, C. Power, T. Quertermous, R. Rauramaa, E. Reinmaa, P.M. Ridker, F. Rivadeneira, J.I. Rotter, T.E. Saaristo, D. Saleheen, D. Schlessinger, P.E. Slagboom, H. Snieder, T.D. Spector, K. Strauch, M. Stumvoll, J. Tuomilehto, M. Uusitupa, P. van der Harst, H. Völzke, M. Walker, N.J. Wareham, H. Watkins, H. Wichmann, J.F. Wilson, P. Zanen, P. Deloukas, I.M. Heid, C.M. Lindgren, K.L. Mohlke, E.K. Speliotes, U. Thorsteinsdottir, I. Barroso, C.S. Fox, K.E. North, D.P. Strachan, J.S. Beckmann, S.I. Berndt, M. Boehnke, I.B. Borecki, M.I. Mccarthy, A. Metspalu, K. Stefansson, A.G. Uitterlinden, C.M. van Duijn, L. Franke, C.J. Willer, A.L. Price, G. Lettre, R.J.F. Loos, M.N. Weedon, E. Ingelsson, J.R. O'Connell, G.R. Abecasis, D.I. Chasman, M.E. Goddard, P.M. Visscher, J.N. Hirschhorn, T.M. Frayling. - In: NATURE GENETICS. - ISSN 1061-4036. - 46:11(2014 Nov), pp. 1173-1186. [10.1038/ng.3097]
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.