Hyperforin is a natural phloroglucinol that has been know for the treatment of depression. Hyperforin displays also antibacterial, antiproliferant and antiangiogenic activity. Synthetic derivatives of hyperforin have also recently been reported to possess increased bioactivity. The clinical applications are limited by the hydrophobic characteristics and the instability of the molecule. In this review we discuss about some of the derivatives of hyperforin (aristoforin, tetrahydrohyperforin and octahydrohyperforin) that demonstrated promising antitumor activity. Among these, octahydrohyperforin also possesses antibacterial activity against both the planktonic and biofilm states of bacteria.
Anticancer and antibacterial activity of hyperforin and its derivatives / B.I.P. Schiavone, L. Verotta, A. Rosato, M. Muraglia, S. Gibbons, E. Bombardelli, C. Franchini, F. Corbo. - In: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. - ISSN 1871-5206. - 14:10(2014), pp. 1397-1401.
|Titolo:||Anticancer and antibacterial activity of hyperforin and its derivatives|
VEROTTA, LUISELLA (Secondo)
|Parole Chiave:||Anti-angiogenic; Antibacterial; Anticancer; Biofilm; Hyperforin; Hyperforin-derivatives; Proapoptotic|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2174/1871520614999140829122803|
|Appare nelle tipologie:||01 - Articolo su periodico|