Swellable/erodible hydroxypropyl cellulose (HPC)-based capsular devices for pulsatile release were prepared by injection molding (IM) using a purposely-devised mold and a newly set up manufacturing process. As compared with previous IM systems of the same composition, such capsules demonstrated improved closure mechanism, technological properties, especially in terms of reproducibility of the shell thickness, and release performance.
Development of Injection-Molded Swellable/Erodible Capsules for Oral Pulsatile Release / L. Zema, G. Loreti, E. Macchi, M. Cerea, A. Foppoli, A. Gazzaniga - In: Proceedings of 2012 CRS Annual Meeting and Exposition[s.l] : CRS (Controlled Release Society), 2012 Jul. (( Intervento presentato al 39. convegno Annual Meeting & Exposition of the Controlled Release Society tenutosi a Québec City nel 2102.
Development of Injection-Molded Swellable/Erodible Capsules for Oral Pulsatile Release
L. ZemaPrimo
;G. LoretiSecondo
;E. Macchi;M. Cerea;A. Foppoli;A. GazzanigaUltimo
2012
Abstract
Swellable/erodible hydroxypropyl cellulose (HPC)-based capsular devices for pulsatile release were prepared by injection molding (IM) using a purposely-devised mold and a newly set up manufacturing process. As compared with previous IM systems of the same composition, such capsules demonstrated improved closure mechanism, technological properties, especially in terms of reproducibility of the shell thickness, and release performance.
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