The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (PSI ≥ 91 points). Blood and sputum samples were collected upon admission. Compared to non-severe CAP patients, the severe CAP group showed higher plasma levels of pro- and anti-inflammatory cytokines but in contrast, lower sputum concentrations of pro-inflammatory cytokines. Blood neutrophil functional responses were elevated in CAP patients compared to healthy controls. However, neutrophils from severe CAP patients showed reduced respiratory burst activity compared to the non-severe group. Results indicate that patients with severe CAP fail to mount a robust local pro-inflammatory response but exhibit instead a more substantial systemic inflammatory response, suggesting that a key driver of CAP severity may be the ability of the patient to generate an optimal local inflammatory response. © 2014 Springer Science+Business Media New York.
Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia / R. Fernandez-Botran, S.M. Uriarte, F.W. Arnold, L. Rodriguez-Hernandez, M.J. Rane, P. Peyrani, T. Wiemken, R. Kelley, S. Uppatla, R. Cavallazzi, F. Blasi, L. Morlacchi, S. Aliberti, C. Jonsson, J.A. Ramirez, J. Bordon. - In: INFLAMMATION. - ISSN 0360-3997. - 37:4(2014), pp. 1158-1166. [10.1007/s10753-014-9840-2]
Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia
F. Blasi;L. Morlacchi;S. Aliberti;
2014
Abstract
The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (PSI ≥ 91 points). Blood and sputum samples were collected upon admission. Compared to non-severe CAP patients, the severe CAP group showed higher plasma levels of pro- and anti-inflammatory cytokines but in contrast, lower sputum concentrations of pro-inflammatory cytokines. Blood neutrophil functional responses were elevated in CAP patients compared to healthy controls. However, neutrophils from severe CAP patients showed reduced respiratory burst activity compared to the non-severe group. Results indicate that patients with severe CAP fail to mount a robust local pro-inflammatory response but exhibit instead a more substantial systemic inflammatory response, suggesting that a key driver of CAP severity may be the ability of the patient to generate an optimal local inflammatory response. © 2014 Springer Science+Business Media New York.Pubblicazioni consigliate
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