NMR experiments, transferred NOE and Saturation Transfer Difference, were used to shed light on the binding epitope of a small library of DKP - RGD peptidomimetics with integrins alphavbeta3, expressed on the membrane of ECV304 bladder cancer cells, and alpha5beta1, overexpressed on the membrane of MDA-MB-231 breast adenocarcinoma cells.
A Comprehensive NMR Analysis of the Interaction between DKP-RGD Ligands and Membrane Proteins on Intact Cells / I. Guzzetti, D. Potenza, F. Vasile, L. Belvisi, M. Civera, I. Silvestri, U. Piarulli, C. Gennari. ((Intervento presentato al convegno SMASH Small Molecule NMR Conference tenutosi a Santiago de Compostela nel 2013.
A Comprehensive NMR Analysis of the Interaction between DKP-RGD Ligands and Membrane Proteins on Intact Cells
I. GuzzettiPrimo
;D. PotenzaSecondo
;F. Vasile;L. Belvisi;M. Civera;I. Silvestri;C. GennariUltimo
2013
Abstract
NMR experiments, transferred NOE and Saturation Transfer Difference, were used to shed light on the binding epitope of a small library of DKP - RGD peptidomimetics with integrins alphavbeta3, expressed on the membrane of ECV304 bladder cancer cells, and alpha5beta1, overexpressed on the membrane of MDA-MB-231 breast adenocarcinoma cells.
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